Gene Information
Gene NameILF3
OrganismHomo sapiens (Human)
Gene Length894
Protein NamesInterleukin enhancer-binding factor 3 (Double-stranded RNA-binding protein 76) (DRBP76) (M-phase phosphoprotein 4) (MPP4) (Nuclear factor associated with dsRNA) (NFAR) (Nuclear factor of activated T-cells 90 kDa) (NF-AT-90) (Translational control protein 80) (TCP80)
Target NameNA
Target TypeNA
Gene Age987 ( ENSG00000129351 )
Evolutionary StageEumetazoa
AlphaFoldDBQ12906
Gene CardILF3
Uniprot IDQ12906
PfamPF00035; PF07528
In ASDno
Allosteric Predictionyes (0.419285103)
Ortholog in AnimalsAlpaca_ ILF3 ( ortholog_one2one )
Dog_ ILF3 ( ortholog_one2one )
GuineaPig_ ILF3 ( ortholog_one2one )
Macaque_ ILF3 ( ortholog_one2one )
Mouse_ Ilf3 ( ortholog_one2one )
Pig_ ILF3 ( ortholog_one2one )
Rat_ Ilf3 ( ortholog_one2one )
Rabbit_ ILF3 ( ortholog_one2one )
OhnologsZFR2, STRBP
ParalogsTARBP2, ADAT1, ADARB2, PRKRA, STRBP, ZFR, ADAD1, ADARB1, STAU2, ILF2, ZFR2, STAU1, ADAR, ADAD2
TissueNA
Tissue SpecificityUbiquitous.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2L33  (NMR  -  )  3P1X  (X-ray  1.90A  )  7RJM  (X-ray  2.10A  )  7RJQ  (X-ray  1.72A  ) 
DBSNP rs1064493  rs34520379 
Subcellular location [CC]Nucleus, nucleolus {ECO:0000269|PubMed:26240280}. Cytoplasm {ECO:0000269|PubMed:28625552}. Nucleus {ECO:0000269|PubMed:10749851, ECO:0000269|PubMed:26240280, ECO:0000269|PubMed:28625552}. Note=Localizes in the cytoplasm in response to viral infection. The unphosphorylated form is retained in the nucleus by ILF2. Phosphorylation at Thr-188 and Thr-315 causes the dissociation of ILF2 from the ILF2-ILF3 complex resulting in a cytoplasmic sequestration of ILF3. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. {ECO:0000269|PubMed:21123651}.
Mouse PG classificationNA
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