| Gene Information | |
|---|---|
| Gene Name | VCAN |
| Organism | Homo sapiens (Human) |
| Gene Length | 3396 |
| Protein Names | Versican core protein (Chondroitin sulfate proteoglycan core protein 2) (Chondroitin sulfate proteoglycan 2) (Glial hyaluronate-binding protein) (GHAP) (Large fibroblast proteoglycan) (PG-M) |
| Target Name | versican core protein |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000038427 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | NA |
| Gene Card | VCAN |
| Uniprot ID | P13611 |
| Pfam | PF00008; PF00059; PF00084; PF07686; PF00193 |
| In ASD | no |
| Allosteric Prediction | no (-0.194471351) |
| Ortholog in Animals | Alpaca_ VCAN ( ortholog_one2one ) Dog_ VCAN ( ortholog_one2one ) Macaque_ VCAN ( ortholog_one2one ) Mouse_ Vcan ( ortholog_one2one ) Pig_ VCAN ( ortholog_one2one ) Rat_ Vcan ( ortholog_one2one ) Rabbit_ VCAN ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | BCAN, HAPLN1, NCAN, ACAN, HAPLN3, HAPLN2, HAPLN4 |
| Tissue | NA |
| Tissue Specificity | Expressed in the retina (at protein level) (PubMed:29777959). Cerebral white matter and plasma (PubMed:2469524). Isoform V0: Expressed in normal brain, gliomas, medulloblastomas, schwannomas, neurofibromas, and meningiomas (PubMed:8627343). Isoform V1: Expressed in normal brain, gliomas, medulloblastomas, schwannomas, neurofibromas, and meningiomas (PubMed:8627343). Isoform V2: Restricted to normal brain and gliomas (PubMed:8627343). Isoform V3: Found in all these tissues except medulloblastomas (PubMed:8627343). {ECO:0000269|PubMed:2469524, ECO:0000269|PubMed:29777959, ECO:0000269|PubMed:8627343}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2652098 rs2287926 rs309559 rs188703 rs160278 rs3734094 rs160277 rs16900532 |
| Subcellular location [CC] | Secreted, extracellular space, extracellular matrix {ECO:0000305|PubMed:2583089}. Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:29777959}. Secreted, extracellular space, extracellular matrix, interphotoreceptor matrix {ECO:0000269|PubMed:29777959}. |
| Mouse PG classification | LPG |
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