| Gene Information | |
|---|---|
| Gene Name | SPIRE2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 714 |
| Protein Names | Protein spire homolog 2 (Spir-2) |
| Target Name | protein spire homolog 2 |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000204991 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q8WWL2 |
| Gene Card | SPIRE2 |
| Uniprot ID | Q8WWL2 |
| Pfam | PF16474 |
| In ASD | no |
| Allosteric Prediction | no (-0.808649948) |
| Ortholog in Animals | Alpaca_ SPIRE2 ( ortholog_one2one ) Dog_ SPIRE2 ( ortholog_one2one ) GuineaPig_ SPIRE2 ( ortholog_one2one ) Macaque_ SPIRE2 ( ortholog_one2one ) Mouse_ Spire2 ( ortholog_one2one ) Pig_ SPIRE2 ( ortholog_one2one ) Rat_ Spire2 ( ortholog_one2one ) Rabbit_ SPIRE2 ( ortholog_one2one ) |
| Ohnologs | SPIRE1 |
| Paralogs | SPIRE1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.066667(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5JCY (X-ray 1.80A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q8K1S6}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8K1S6}. Cell membrane {ECO:0000250|UniProtKB:Q8K1S6}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8K1S6}; Cytoplasmic side {ECO:0000250|UniProtKB:Q8K1S6}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q8K1S6}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8K1S6}; Cytoplasmic side {ECO:0000250|UniProtKB:Q8K1S6}. Note=Detected at the cleavage furrow during asymmetric oocyte division and polar body extrusion. {ECO:0000250|UniProtKB:Q8K1S6}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |