| Gene Information | |
|---|---|
| Gene Name | VAV2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 878 |
| Protein Names | Guanine nucleotide exchange factor VAV2 (VAV-2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000160293 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P52735 |
| Gene Card | VAV2 |
| Uniprot ID | P52735 |
| Pfam | PF00130; PF11971; PF00169; PF00621; PF00017; PF07653 |
| In ASD | no |
| Allosteric Prediction | yes (0.279929974) |
| Ortholog in Animals | Alpaca_ VAV2 ( ortholog_one2one ) Dog_ VAV2 ( ortholog_one2one ) GuineaPig_ VAV2 ( ortholog_one2one ) Macaque_ VAV2 ( ortholog_one2one ) Mouse_ Vav2 ( ortholog_one2one ) Pig_ VAV2 ( ortholog_one2one ) Rat_ Vav2 ( ortholog_one2one ) |
| Ohnologs | VAV1, VAV3 |
| Paralogs | MCF2L2, VAV1, PLEKHN1, PLEKHG4, TIAM2, ARHGEF40, ARHGEF25, VAV3, SPATA13, ARHGEF9, ARHGEF6, PLEKHG1, SESTD1, PLEKHG2, KIAA1755, PLEKHG4B, TIAM1, MCF2, KALRN, ARHGEF7, MCF2L, TRIO |
| Tissue | NA |
| Tissue Specificity | Widely expressed. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002808(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2DLZ (NMR - ) 2DM1 (NMR - ) 2LNW (NMR - ) 2LNX (NMR - ) 4ROJ (X-ray 1.95A ) 7RNV (X-ray 2.15A ) |
| DBSNP | rs602990 |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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