| Gene Information | |
|---|---|
| Gene Name | VAT1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 525 |
| Protein Names | Chromaffin granule amine transporter (Solute carrier family 18 member 1) (Vesicular amine transporter 1) (VAT1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000108828 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P54219 |
| Gene Card | SLC18A1 |
| Uniprot ID | P54219 |
| Pfam | PF07690 |
| In ASD | no |
| Allosteric Prediction | yes (0.082227761) |
| Ortholog in Animals | Alpaca_ VAT1 ( ortholog_one2one ) Dog_ VAT1 ( ortholog_one2one ) GuineaPig_ VAT1 ( ortholog_one2one ) Macaque_ VAT1 ( ortholog_one2one ) Mouse_ Vat1 ( ortholog_one2one ) Pig_ VAT1 ( ortholog_one2one ) Rat_ Vat1 ( ortholog_one2one ) |
| Ohnologs | VAT1L |
| Paralogs | MECR, CRYZ, RTN4IP1, PTGR2, TP53I3, CRYZL1, PTGR3, ADH6, ADH4, SORD, ADH1B, ADH1A, ADH1C, VAT1L, PTGR1, ADH5, ADH7 |
| Tissue | NA |
| Tissue Specificity | Expressed primarily in neuroendocrine tissues. Highly expressed in chromaffin cells of the adrenal medulla (at protein level). Detected in peripheral sympathetic ganglia (at protein level). Found in some paracrine cells in stomach and duodenum (at protein level) (PubMed:8643547). Expressed in substantia nigra (PubMed:23337945). {ECO:0000269|PubMed:23337945, ECO:0000269|PubMed:8643547}.; [Isoform 1]: Expressed in gastrointestinal tract. {ECO:0000269|PubMed:16326835}.; [Isoform 2]: Expressed in gastrointestinal tract. {ECO:0000269|PubMed:16326835}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs2270641 rs150204882 rs17092144 rs17215815 rs17215822 rs17215801 rs2270637 rs17222218 rs1390938 rs148468662 rs17215808 rs17222092 rs17222120 rs17215759 rs17092104 |
| Subcellular location [CC] | Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000269|PubMed:8643547}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q8R090}; Multi-pass membrane protein {ECO:0000255}.; [Isoform 1]: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000269|PubMed:16326835}; Multi-pass membrane protein {ECO:0000255}.; [Isoform 2]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16326835}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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