| Gene Information | |
|---|---|
| Gene Name | VASP |
| Organism | Homo sapiens (Human) |
| Gene Length | 380 |
| Protein Names | Vasodilator-stimulated phosphoprotein (VASP) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000125753 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P50552 |
| Gene Card | VASP |
| Uniprot ID | P50552 |
| Pfam | PF08776; PF00568 |
| In ASD | yes |
| Allosteric Prediction | yes (0.069814007) |
| Ortholog in Animals | Alpaca_ VASP ( ortholog_one2one ) GuineaPig_ VASP ( ortholog_one2one ) Macaque_ VASP ( ortholog_one2one ) Mouse_ Vasp ( ortholog_one2one ) Pig_ VASP ( ortholog_one2one ) Rat_ Vasp ( ortholog_one2one ) |
| Ohnologs | EVL |
| Paralogs | SPRED3, SPRED1, ENAH, SPRED2, EVL |
| Tissue | NA |
| Tissue Specificity | Highly expressed in platelets. {ECO:0000269|PubMed:7828592}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1EGX (NMR - ) 1USD (X-ray 1.70A ) 1USE (X-ray 1.30A ) 2PAV (X-ray 1.80A ) 2PBD (X-ray 1.50A ) 3CHW (X-ray 2.30A ) |
| DBSNP | rs10415373 rs34345197 |
| Subcellular location [CC] | Cytoplasm. Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cell junction, tight junction {ECO:0000250}. Cell projection, lamellipodium membrane. Cell projection, filopodium membrane. Note=Targeted to stress fibers and focal adhesions through interaction with a number of proteins including MRL family members. Localizes to the plasma membrane in protruding lamellipodia and filopodial tips. Stimulation by thrombin or PMA, also translocates VASP to focal adhesions. Localized along the sides of actin filaments throughout the peripheral cytoplasm under basal conditions. In pre-apoptotic cells, colocalizes with MEFV in large specks (pyroptosomes). |
| Mouse PG classification | NA |
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