| Gene Information | |
|---|---|
| Gene Name | VAPB |
| Organism | Homo sapiens (Human) |
| Gene Length | 243 |
| Protein Names | Vesicle-associated membrane protein-associated protein B/C (VAMP-B/VAMP-C) (VAMP-associated protein B/C) (VAP-B/VAP-C) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000124164 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O95292 |
| Gene Card | VAPB |
| Uniprot ID | O95292 |
| Pfam | PF00635 |
| In ASD | no |
| Allosteric Prediction | no (-0.282152878) |
| Ortholog in Animals | Alpaca_ VAPB ( ortholog_one2one ) Dog_ VAPB ( ortholog_one2one ) GuineaPig_ VAPB ( ortholog_one2one ) Mouse_ Vapb ( ortholog_one2one ) Pig_ VAPB ( ortholog_one2one ) Rat_ Vapb ( ortholog_one2one ) Rabbit_ VAPB ( ortholog_one2one ) |
| Ohnologs | VAPA |
| Paralogs | VAPA |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. Isoform 1 predominates. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.005263(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2MDK (NMR - ) 3IKK (X-ray 2.50A ) |
| DBSNP | rs281875284 rs74315431 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Note=Present in mitochondria-associated membranes that are endoplasmic reticulum membrane regions closely apposed to the outer mitochondrial membrane. {ECO:0000269|PubMed:22131369}. |
| Mouse PG classification | HPG |
| click here to return to the previous page | |