| Gene Information | |
|---|---|
| Gene Name | SELE |
| Organism | Homo sapiens (Human) |
| Gene Length | 610 |
| Protein Names | E-selectin (CD62 antigen-like family member E) (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD antigen CD62E) |
| Target Name | e-selectin |
| Target Type | Clinical trial target |
| Gene Age | 544 ( ENSG00000007908 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P16581 |
| Gene Card | SELE |
| Uniprot ID | P16581 |
| Pfam | PF00008; PF00059; PF00084 |
| In ASD | no |
| Allosteric Prediction | yes (0.721473189) |
| Ortholog in Animals | Alpaca_ SELE ( ortholog_one2one ) Dog_ SELE ( ortholog_one2one ) GuineaPig_ SELE ( ortholog_one2one ) Macaque_ SELE ( ortholog_one2one ) Mouse_ Sele ( ortholog_one2one ) Rat_ Sele ( ortholog_one2one ) Rabbit_ SELE ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CR1L, SUSD3, F13B, SELP, SEZ6L2, CFHR2, CFHR1, CSMD1, APOH, SRPX, SVEP1, SEZ6, C8A, CD55, CSMD2, PAPPA2, SUSD6, C4BPA, C9, CR1, PAPPA, SELL, CFB, CD46, C4BPB, CR2, C7, CSMD3, CFHR3, CFH, SEZ6L, CFHR4, CFHR5, SRPX2, C8B, PRF1, SUSD4, C6, C2 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1ESL (X-ray 2.00A ) 1G1T (X-ray 1.50A ) 4C16 (X-ray 1.93A ) 4CSY (X-ray 2.41A ) 6EYI (X-ray 2.04A ) 6EYJ (X-ray 2.20A ) 6EYK (X-ray 2.21A ) |
| DBSNP | rs3917407 rs3917408 rs5360 rs5361 rs3917422 rs5364 rs5366 rs5368 rs3917429 rs5355 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:12649084, ECO:0000269|PubMed:28011641}; Single-pass type I membrane protein. |
| Mouse PG classification | NA |
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