| Gene Information | |
|---|---|
| Gene Name | VAMP7 |
| Organism | Homo sapiens (Human) |
| Gene Length | 220 |
| Protein Names | Vesicle-associated membrane protein 7 (VAMP-7) (Synaptobrevin-like protein 1) (Tetanus-insensitive VAMP) (Ti-VAMP) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000124333 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P51809 |
| Gene Card | VAMP7 |
| Uniprot ID | P51809 |
| Pfam | PF13774; PF00957 |
| In ASD | no |
| Allosteric Prediction | no (-0.06540431) |
| Ortholog in Animals | Alpaca_ VAMP7 ( ortholog_one2one ) Dog_ VAMP7 ( ortholog_one2one ) GuineaPig_ VAMP7 ( ortholog_one2one ) Macaque_ VAMP7 ( ortholog_one2one ) Pig_ VAMP7 ( ortholog_one2one ) Rat_ Vamp7 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | VAMP8, VAMP2, SEC22A, VAMP3, VAMP4, VAMP1, SEC22C, VAMP5, SEC22B, YKT6 |
| Tissue | NA |
| Tissue Specificity | Detected in all tissues tested. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.181590(Rat);0.054977(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2DMW (NMR - ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Late endosome membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Lysosome membrane {ECO:0000269|PubMed:17897319}; Single-pass type IV membrane protein {ECO:0000269|PubMed:17897319}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Synapse, synaptosome {ECO:0000250}. Note=In immature neurons expression is localized in vesicular structures in axons and dendrites while in mature neurons it is localized to the somatodendritic region. Colocalizes with LAMP1 in kidney cells. Localization to the endoplasmic reticulum membrane was observed in the intestine but not in liver or kidney (By similarity). {ECO:0000250}. |
| Mouse PG classification | NA |
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