| Gene Information | |
|---|---|
| Gene Name | GFRA4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 299 |
| Protein Names | GDNF family receptor alpha-4 (GDNF receptor alpha-4) (GDNFR-alpha-4) (GFR-alpha-4) (Persephin receptor) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000125861 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q9GZZ7 |
| Gene Card | GFRA4 |
| Uniprot ID | Q9GZZ7 |
| Pfam | PF02351 |
| In ASD | no |
| Allosteric Prediction | no (-0.370382388) |
| Ortholog in Animals | Alpaca_ GFRA4 ( ortholog_one2one ) Dog_ GFRA4 ( ortholog_one2one ) GuineaPig_ GFRA4 ( ortholog_one2one ) Macaque_ GFRA4 ( ortholog_one2one ) Mouse_ Gfra4 ( ortholog_one2one ) Pig_ GFRA4 ( ortholog_one2one ) Rat_ Gfra4 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | GFRA1, GFRA2, GFRA3, GFRAL |
| Tissue | NA |
| Tissue Specificity | Predominantly expressed in the adult thyroid gland. Low levels also found in fetal adrenal and thyroid glands. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | [Isoform GFRalpha4a]: Cell membrane; Lipid-anchor, GPI-anchor.; [Isoform GFRalpha4b]: Cell membrane; Lipid-anchor, GPI-anchor.; [Isoform GFRalpha4c]: Secreted. |
| Mouse PG classification | NA |
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