Gene Information
Gene NameVAM6
OrganismHomo sapiens (Human)
Gene Length886
Protein NamesVam6/Vps39-like protein (TRAP1-like protein) (hVam6p)
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBQ96JC1
Gene CardVPS39
Uniprot IDQ96JC1
PfamPF00780; PF10366; PF10367
In ASDno
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityWidely expressed, with highest levels in heart, skeletal muscle, kidney, pancreas, brain, placenta and spleen. {ECO:0000269|PubMed:11448994, ECO:0000269|PubMed:12941698}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.029268(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 6ZE9  (X-ray  2.90A 
DBSNP NA 
Subcellular location [CC]Cytoplasm. Lysosome membrane {ECO:0000269|PubMed:11448994, ECO:0000269|PubMed:17897319, ECO:0000269|PubMed:23167963};
Peripheral membrane protein {ECO:0000305|PubMed:11448994}. Late endosome membrane {ECO:0000269|PubMed:11448994, ECO:0000269|PubMed:23167963};
Peripheral membrane protein {ECO:0000305|PubMed:11448994}. Note=Colocalizes with TGFBR1 and TGFBR2 in cytoplasmic vesicular structures and most prominently in cortical vesicles. {ECO:0000269|PubMed:12941698}.;
Note=(Microbial infection) Sequestrated at the late endosome by SARS coronavirus-2/SARS-CoV-2 ORF3A protein. {ECO:0000269|PubMed:33422265}.
Mouse PG classificationNA
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