Gene Information | |
---|---|
Gene Name | VAM6 |
Organism | Homo sapiens (Human) |
Gene Length | 886 |
Protein Names | Vam6/Vps39-like protein (TRAP1-like protein) (hVam6p) |
Target Name | NA |
Target Type | NA |
Gene Age | NA |
Evolutionary Stage | NA |
AlphaFoldDB | Q96JC1 |
Gene Card | VPS39 |
Uniprot ID | Q96JC1 |
Pfam | PF00780; PF10366; PF10367 |
In ASD | no |
Allosteric Prediction | NA |
Ortholog in Animals | NA |
Ohnologs | NA |
Paralogs | NA |
Tissue | NA |
Tissue Specificity | Widely expressed, with highest levels in heart, skeletal muscle, kidney, pancreas, brain, placenta and spleen. {ECO:0000269|PubMed:11448994, ECO:0000269|PubMed:12941698}. |
Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.029268(Rabbit) |
Gene Ontology (biological process) |
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Gene Ontology (cellular component) |
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Gene Ontology (molecular function) |
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PDB | 6ZE9 (X-ray 2.90A ) |
DBSNP | NA |
Subcellular location [CC] | Cytoplasm. Lysosome membrane {ECO:0000269|PubMed:11448994, ECO:0000269|PubMed:17897319, ECO:0000269|PubMed:23167963}; Peripheral membrane protein {ECO:0000305|PubMed:11448994}. Late endosome membrane {ECO:0000269|PubMed:11448994, ECO:0000269|PubMed:23167963}; Peripheral membrane protein {ECO:0000305|PubMed:11448994}. Note=Colocalizes with TGFBR1 and TGFBR2 in cytoplasmic vesicular structures and most prominently in cortical vesicles. {ECO:0000269|PubMed:12941698}.; Note=(Microbial infection) Sequestrated at the late endosome by SARS coronavirus-2/SARS-CoV-2 ORF3A protein. {ECO:0000269|PubMed:33422265}. |
Mouse PG classification | NA |
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