| Gene Information | |
|---|---|
| Gene Name | UTRN |
| Organism | Homo sapiens (Human) |
| Gene Length | 3433 |
| Protein Names | Utrophin (Dystrophin-related protein 1) (DRP-1) |
| Target Name | utrophin |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000152818 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | NA |
| Gene Card | UTRN |
| Uniprot ID | P46939 |
| Pfam | PF00307; PF09068; PF09069; PF00435; PF00569 |
| In ASD | no |
| Allosteric Prediction | yes (0.183669377) |
| Ortholog in Animals | Alpaca_ UTRN ( ortholog_one2one ) Dog_ UTRN ( ortholog_one2one ) GuineaPig_ UTRN ( ortholog_one2one ) Macaque_ UTRN ( ortholog_one2one ) Mouse_ Utrn ( ortholog_one2one ) Pig_ UTRN ( ortholog_one2one ) Rat_ Utrn ( ortholog_one2one ) Rabbit_ UTRN ( ortholog_one2one ) |
| Ohnologs | DMD |
| Paralogs | DSP, SPTBN5, ACTN4, MICAL2, DMD, SYNE3, GAS2L2, SPTBN2, FLNB, SPTAN1, SYNE2, PLEC, EPPK1, SYNE1, CLMN, DYTN, MICAL3, PKHD1, SMTNL2, PKHD1L1, ACTN2, ACTN3, MICAL1, SPTBN1, MACF1, ACTN1, DST, SPTB, GAS2L3, FLNC, FLNA, DTNA, SPTA1, DTNB, SPTBN4, DRP2 |
| Tissue | NA |
| Tissue Specificity | Isoform 1 has high expression in muscle. Isoforms Up70 and Up140 were found in all the adult and fetal tissues tested and relatively abundant in lung and kidney. {ECO:0000269|PubMed:10369873}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.007692(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1BHD (X-ray 2.00A ) 1QAG (X-ray 3.00A ) 6M5G (EM 3.60A ) |
| DBSNP | rs12204715 rs12204734 rs35676466 rs1534443 |
| Subcellular location [CC] | Postsynaptic cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Note=Neuromuscular junction. |
| Mouse PG classification | NA |
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