Gene Information
Gene NameDAPK3
OrganismHomo sapiens (Human)
Gene Length454
Protein NamesDeath-associated protein kinase 3 (DAP kinase 3) (EC 2.7.11.1) (DAP-like kinase) (Dlk) (MYPT1 kinase) (Zipper-interacting protein kinase) (ZIP-kinase)
Target Namedeath-associated protein kinase 3
Target TypeNA
Gene Age454 ( ENSG00000167657 )
Evolutionary StageEukaryota
AlphaFoldDBO43293
Gene CardDAPK3
Uniprot IDO43293
PfamPF00069
In ASDno
Allosteric Predictionyes (0.271055372)
Ortholog in AnimalsAlpaca_ DAPK3 ( ortholog_one2one )
Dog_ DAPK3 ( ortholog_one2one )
GuineaPig_ DAPK3 ( ortholog_one2one )
Mouse_ Dapk3 ( ortholog_one2one )
Pig_ DAPK3 ( ortholog_one2one )
Rat_ Dapk3 ( ortholog_one2one )
OhnologsDAPK2
ParalogsDAPK1, DAPK2, MYLK, NEXN
TissueNA
Tissue SpecificityWidely expressed. Isoform 1 and isoform 2 are expressed in the bladder smooth muscle. {ECO:0000269|PubMed:15292222, ECO:0000269|PubMed:17126281}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1YRP  (X-ray  3.10A  )  2J90  (X-ray  2.00A  )  3BHY  (X-ray  1.24A  )  3BQR  (X-ray  1.75A  )  5A6N  (X-ray  1.70A  )  5A6O  (X-ray  1.60A  )  5VJA  (X-ray  2.46A  ) 
DBSNP NA 
Subcellular location [CC]Nucleus {ECO:0000269|PubMed:15367680, ECO:0000269|PubMed:15910542, ECO:0000269|PubMed:20854903}. Cytoplasm {ECO:0000269|PubMed:15367680, ECO:0000269|PubMed:15611134, ECO:0000269|PubMed:17953487, ECO:0000269|PubMed:20854903}. Note=Predominantly localizes to the cytoplasm but can shuttle between the nucleus and cytoplasm;
cytoplasmic localization is promoted by phosphorylation at Thr-299 and involves Rho/Rock signaling. {ECO:0000269|PubMed:17953487, ECO:0000269|PubMed:20854903}.;
[Isoform 1]: Nucleus {ECO:0000269|PubMed:17126281}. Cytoplasm {ECO:0000269|PubMed:17126281}.;
[Isoform 2]: Nucleus {ECO:0000269|PubMed:17126281}. Cytoplasm {ECO:0000269|PubMed:17126281}.
Mouse PG classificationNA
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