| Gene Information | |
|---|---|
| Gene Name | TLR3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 904 |
| Protein Names | Toll-like receptor 3 (CD antigen CD283) |
| Target Name | toll-like receptor 3 |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000164342 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O15455 |
| Gene Card | TLR3 |
| Uniprot ID | O15455 |
| Pfam | PF13516; PF13855; PF01582; PF17968 |
| In ASD | no |
| Allosteric Prediction | yes (0.494956682) |
| Ortholog in Animals | Alpaca_ TLR3 ( ortholog_one2one ) Dog_ TLR3 ( ortholog_one2one ) GuineaPig_ TLR3 ( ortholog_one2one ) Macaque_ TLR3 ( ortholog_one2one ) Mouse_ Tlr3 ( ortholog_one2one ) Pig_ TLR3 ( ortholog_one2one ) Rat_ Tlr3 ( ortholog_one2one ) Rabbit_ TLR3 ( ortholog_one2one ) |
| Ohnologs | TLR8, LRRC32, TLR7 |
| Paralogs | CD180, RXFP1, TLR8, NRROS, TLR5, TSKU, TLR7, TLR10, RXFP2, TLR6, LRRC3B, IGFALS, TLR2, TLR4, LRRC17, LRRC32, LRRC53, VASN, TLR1, LRRC3C, LRRC3, LRIT2 |
| Tissue | NA |
| Tissue Specificity | Expressed at high level in placenta and pancreas. Also detected in CD11c+ immature dendritic cells. Only expressed in dendritic cells and not in other leukocytes, including monocyte precursors. TLR3 is the TLR that is expressed most strongly in the brain, especially in astrocytes, glia, and neurons. {ECO:0000269|PubMed:17085778}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.028571(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1ZIW (X-ray 2.10A ) 2A0Z (X-ray 2.40A ) 2MK9 (NMR - ) 2MKA (NMR - ) 3ULU (X-ray 3.52A ) 3ULV (X-ray 3.52A ) 5GS0 (X-ray 3.27A ) 7C76 (EM 3.40A ) |
| DBSNP | rs780051344 rs5743316 rs5743317 rs3775291 rs121434431 rs774476397 rs5743318 rs199768900 |
| Subcellular location [CC] | Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome membrane. Early endosome {ECO:0000269|PubMed:25736436}. |
| Mouse PG classification | NA |
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