| Gene Information | |
|---|---|
| Gene Name | PARK9 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1180 |
| Protein Names | Polyamine-transporting ATPase 13A2 (EC 7.6.2.-) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9NQ11 |
| Gene Card | ATP13A2 |
| Uniprot ID | Q9NQ11 |
| Pfam | PF12409 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in brain; protein levels are markedly increased in brain from subjects with Parkinson disease and subjects with dementia with Lewy bodies. Detected in pyramidal neurons located throughout the cingulate cortex (at protein level). In the substantia nigra, it is found in neuromelanin-positive dopaminergic neurons (at protein level). {ECO:0000269|PubMed:22186024}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7M5V (EM 2.90A ) 7M5X (EM 2.70A ) 7M5Y (EM 3.00A ) 7N70 (EM 2.80A ) 7N72 (EM 2.50A ) 7N73 (EM 2.90A ) 7N74 (EM 2.80A ) 7N75 (EM 2.90A ) 7N76 (EM 2.90A ) 7N77 (EM 3.20A ) 7N78 (EM 3.00A ) 7VPI (EM 3.50A ) 7VPJ (EM 3.50A ) 7VPK (EM 3.50A ) 7VPL (EM 3.50A ) |
| DBSNP | rs151117874 rs56379718 rs56367069 rs56275621 rs772446950 rs121918227 rs1057519291 rs56186751 rs147277743 rs55635527 rs56170027 rs587777053 rs144701072 rs55708915 rs137853967 rs774238872 |
| Subcellular location [CC] | Lysosome membrane {ECO:0000269|PubMed:21542062, ECO:0000269|PubMed:22186024, ECO:0000269|PubMed:22768177, ECO:0000269|PubMed:24603074, ECO:0000269|PubMed:26134396, ECO:0000269|PubMed:28137957}; Multi-pass membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:24603074, ECO:0000269|PubMed:25392495, ECO:0000269|PubMed:26134396}; Multi-pass membrane protein {ECO:0000255}. Endosome, multivesicular body membrane {ECO:0000269|PubMed:24603074, ECO:0000269|PubMed:25392495}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:24603074}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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