| Gene Information | |
|---|---|
| Gene Name | USP8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1118 |
| Protein Names | Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin isopeptidase Y) (hUBPy) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000138592 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P40818 |
| Gene Card | USP8 |
| Uniprot ID | P40818 |
| Pfam | PF00581; PF00443; PF08969 |
| In ASD | no |
| Allosteric Prediction | yes (0.430553642) |
| Ortholog in Animals | Alpaca_ USP8 ( ortholog_one2one ) Dog_ USP8 ( ortholog_one2one ) GuineaPig_ USP8 ( ortholog_one2one ) Macaque_ USP8 ( ortholog_one2one ) Mouse_ Usp8 ( ortholog_one2one ) Pig_ USP8 ( ortholog_one2one ) Rat_ Usp8 ( ortholog_one2one ) Rabbit_ USP8 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | USP11, USP20, USP4, USP5, USP42, USP14, USP29, USP25, USP48, USP2, USP47, USP40, USP3, USP1, USP34, USP21, USP24, USP38, USP32, USP6, USP31, USP50, USP13, USP7, USP43, USP17L4, USP17L11, USP17L27, USP17L22, USP17L30, USP17L17, USP17L26, USP17L25, USP17L12, USP17L10, USP17L28, USP17L1, USP17L5, USP17L24, USP17L21, USP17L3, USP17L29, USP17L18, USP17L13, USP17L15, USP17L7, USP17L23, USP17L2, USP17L20, USP17L8, USP17L19, USP35, USP45, USP33, USP49, USP51, USP19, USP15, USP28, USP9X, USP9Y, USP27X, USP44, USP18, USP30, USP10, USP22, USP26, USP16, USP37, USP36 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.492874(Rat);0.181980(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1WHB (NMR - ) 2A9U (X-ray 2.10A ) 2GFO (X-ray 2.00A ) 2GWF (X-ray 2.30A ) 3N3K (X-ray 2.60A ) 6F09 (X-ray 1.59A ) |
| DBSNP | rs587777201 rs3743044 rs672601308 rs672601307 rs672601311 rs11638390 rs1056577 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:16520378, ECO:0000269|PubMed:17711858, ECO:0000269|PubMed:19427866, ECO:0000269|PubMed:28505279}. Nucleus {ECO:0000250|UniProtKB:Q80U87}. Endosome membrane {ECO:0000269|PubMed:16520378, ECO:0000269|PubMed:17711858}; Peripheral membrane protein {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:16520378}; Peripheral membrane protein {ECO:0000305}. |
| Mouse PG classification | NA |
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