Gene Information
Gene NameCALCRL
OrganismHomo sapiens (Human)
Gene Length461
Protein NamesCalcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor)
Target Namecalcitonin gene-related peptide type 1 receptor
Target TypeNA
Gene Age645 ( ENSG00000064989 )
Evolutionary StageEumetazoa
AlphaFoldDBQ16602
Gene CardCALCRL
Uniprot IDQ16602
PfamPF00002; PF02793
In ASDyes
Allosteric Predictionyes (1.079094054)
Ortholog in AnimalsAlpaca_ CALCRL ( ortholog_one2one )
Dog_ CALCRL ( ortholog_one2one )
GuineaPig_ CALCRL ( ortholog_one2one )
Macaque_ CALCRL ( ortholog_one2one )
Mouse_ Calcrl ( ortholog_one2one )
Pig_ CALCRL ( ortholog_one2one )
Rat_ Calcrl ( ortholog_one2one )
Rabbit_ CALCRL ( ortholog_one2one )
OhnologsCALCR, GLP1R, VIPR1
ParalogsADGRE3, ADGRL2, VIPR1, ADGRL4, ADGRE2, ADGRG4, ADGRD1, ADGRL3, GHRHR, PTH2R, ADGRE1, ADGRD2, ADGRL1, ADGRB3, EVA1C, ADGRG1, SCTR, ADGRF5, ADGRA3, GLP2R, PTH1R, CALCR, ADGRF3, GIPR, ADGRA1, ADGRF1, ADCYAP1R1, ADGRG5, ADGRE5, CRHR2, ADGRB2, ADGRG6, GCGR, ADGRB1, ADGRG2, ADGRA2, ADGRF4, VIPR2, ADGRG7, ADGRG3, CRHR1, GLP1R
TissueNA
Tissue SpecificityPredominantly expressed in the lung and heart.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.108747(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 3AQF  (X-ray  2.60A  3N7P  (X-ray  2.80A  3N7R  (X-ray  2.90A  3N7S  (X-ray  2.10A  4RWF  (X-ray  1.76A  4RWG  (X-ray  2.44A  5V6Y  (X-ray  2.80A  6D1U  (X-ray  2.05A  6E3Y  (EM  3.30A  6UMG  (X-ray  2.70A  6UUN  (EM  3.00A  6UUS  (EM  2.40A  6UVA  (EM  2.30A  6V2E  (X-ray  1.83A  6ZHO  (X-ray  1.60A  6ZIS  (X-ray  1.73A  7KNT  (EM  3.15A  7KNU  (EM  3.49A  7P0F  (X-ray  1.85A  7P0I  (X-ray  2.30A 
DBSNP rs698577  rs13391909  rs34010553 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:30115739};
Multi-pass membrane protein.
Mouse PG classificationNA
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