| Gene Information | |
|---|---|
| Gene Name | USP6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1406 |
| Protein Names | Ubiquitin carboxyl-terminal hydrolase 6 (EC 3.4.19.12) (Deubiquitinating enzyme 6) (Proto-oncogene TRE-2) (Ubiquitin thioesterase 6) (Ubiquitin-specific-processing protease 6) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000129204 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P35125 |
| Gene Card | USP6 |
| Uniprot ID | P35125 |
| Pfam | PF00566; PF00443 |
| In ASD | no |
| Allosteric Prediction | no (-0.824662695) |
| Ortholog in Animals | Alpaca_ USP6 ( ortholog_one2one ) Mouse_ Usp32 ( ortholog_one2many ) Rat_ Usp32 ( ortholog_one2many ) |
| Ohnologs | USP32 |
| Paralogs | USP32, USP11, USP20, USP4, USP5, USP42, USP14, USP29, USP25, USP48, USP2, USP47, USP40, USP3, USP1, USP34, USP8, USP21, USP24, USP38, USP31, USP50, USP13, USP7, USP43, USP17L4, USP17L11, USP17L27, USP17L22, USP17L30, USP17L17, USP17L26, USP17L25, USP17L12, USP17L10, USP17L28, USP17L1, USP17L5, USP17L24, USP17L21, USP17L3, USP17L29, USP17L18, USP17L13, USP17L15, USP17L7, USP17L23, USP17L2, USP17L20, USP17L8, USP17L19, USP35, USP45, USP33, USP49, USP51, USP19, USP15, USP28, USP9X, USP9Y, USP27X, USP44, USP18, USP30, USP10, USP22, USP26, USP16, USP37, USP36 |
| Tissue | testis |
| Tissue Specificity | Testis specific. Expressed in various cancer cell lines. {ECO:0000269|PubMed:12604796, ECO:0000269|PubMed:1565468}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs8073787 rs2304449 rs9899177 |
| Subcellular location [CC] | Cell membrane. Cytoplasm. Endosome. Note=Localizes to the plasma membrane and to filamentous structures within the cell corresponding to ARF6 regulated tubular endosomes. Activation of RAC1 and CDC42 can direct the relocalization of USP6 to the plasma membrane in a manner that depends on the integrity of the actin cytoskeleton. |
| Mouse PG classification | NA |
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