Gene Information
Gene NameUSP45
OrganismHomo sapiens (Human)
Gene Length814
Protein NamesUbiquitin carboxyl-terminal hydrolase 45 (EC 3.4.19.12) (Deubiquitinating enzyme 45) (Ubiquitin thioesterase 45) (Ubiquitin-specific-processing protease 45)
Target NameNA
Target TypeNA
Gene Age645 ( ENSG00000123552 )
Evolutionary StageEukaryota
AlphaFoldDBQ70EL2
Gene CardUSP45
Uniprot IDQ70EL2
PfamPF00443; PF02148
In ASDno
Allosteric Predictionno (-1.019678643)
Ortholog in AnimalsAlpaca_ USP45 ( ortholog_one2one )
GuineaPig_ USP45 ( ortholog_one2one )
Macaque_ USP45 ( ortholog_one2one )
Mouse_ Usp45 ( ortholog_one2one )
Pig_ USP45 ( ortholog_one2one )
Rat_ Usp45 ( ortholog_one2one )
Rabbit_ USP45 ( ortholog_one2one )
OhnologsUSP16
ParalogsUSP11, USP20, USP4, USP5, USP42, USP14, USP29, USP25, USP48, USP2, USP47, USP40, USP3, USP1, USP34, USP8, USP21, USP24, USP38, USP32, USP6, USP31, USP50, USP13, USP7, USP43, USP17L4, USP17L11, USP17L27, USP17L22, USP17L30, USP17L17, USP17L26, USP17L25, USP17L12, USP17L10, USP17L28, USP17L1, USP17L5, USP17L24, USP17L21, USP17L3, USP17L29, USP17L18, USP17L13, USP17L15, USP17L7, USP17L23, USP17L2, USP17L20, USP17L8, USP17L19, USP35, USP33, USP49, USP51, USP19, USP15, USP28, USP9X, USP9Y, USP27X, USP44, USP18, USP30, USP10, USP22, USP26, USP16, USP37, USP36
TissueNA
Tissue SpecificityWidely expressed. High expression is detected in the cerebellum. In the eye, it is expressed at high levels in the optic nerve, sclera and retina, with relatively low levels in the choroid, lens and retinal pigment epithelium (PubMed:30573563). {ECO:0000269|PubMed:14715245, ECO:0000269|PubMed:30573563}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs7744845  rs41288947  rs6570065 
Subcellular location [CC]Photoreceptor inner segment {ECO:0000269|PubMed:30573563}. Cytoplasm {ECO:0000269|PubMed:25538220}. Nucleus {ECO:0000269|PubMed:25538220}.
Mouse PG classificationNA
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