| Gene Information | |
|---|---|
| Gene Name | CANPL1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 714 |
| Protein Names | Calpain-1 catalytic subunit (EC 3.4.22.52) (Calcium-activated neutral proteinase 1) (CANP 1) (Calpain mu-type) (Calpain-1 large subunit) (Cell proliferation-inducing gene 30 protein) (Micromolar-calpain) (muCANP) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P07384 |
| Gene Card | CAPN1 |
| Uniprot ID | P07384 |
| Pfam | PF01067; PF13833; PF00648 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:2400579, ECO:0000269|PubMed:3017764, ECO:0000269|PubMed:8769305, ECO:0000269|PubMed:8954105, ECO:0000269|PubMed:9271093}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001490(Rat);0.02(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1ZCM (X-ray 2.00A ) 2ARY (X-ray 2.40A ) |
| DBSNP | rs17885718 rs756205995 rs10895991 rs17883283 rs17884773 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:21531719, ECO:0000269|PubMed:8769305}. Cell membrane {ECO:0000269|PubMed:8769305}. Note=Translocates to the plasma membrane upon Ca(2+) binding. In granular keratinocytes and in lower corneocytes, colocalizes with FLG and FLG2 (PubMed:21531719). {ECO:0000269|PubMed:21531719}. |
| Mouse PG classification | NA |
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