| Gene Information | |
|---|---|
| Gene Name | USP30 |
| Organism | Homo sapiens (Human) |
| Gene Length | 517 |
| Protein Names | Ubiquitin carboxyl-terminal hydrolase 30 (EC 3.4.19.12) (Deubiquitinating enzyme 30) (Ubiquitin thioesterase 30) (Ubiquitin-specific-processing protease 30) (Ub-specific protease 30) |
| Target Name | ubiquitin carboxyl-terminal hydrolase 30 |
| Target Type | Preclinical target |
| Gene Age | 544 ( ENSG00000135093 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q70CQ3 |
| Gene Card | USP30 |
| Uniprot ID | Q70CQ3 |
| Pfam | PF00443 |
| In ASD | yes |
| Allosteric Prediction | no (-1.006301401) |
| Ortholog in Animals | Alpaca_ USP30 ( ortholog_one2many ) Dog_ USP30 ( ortholog_one2one ) GuineaPig_ USP30 ( ortholog_one2one ) Macaque_ USP30 ( ortholog_one2one ) Mouse_ Usp30 ( ortholog_one2one ) Pig_ USP30 ( ortholog_one2one ) Rat_ Usp30 ( ortholog_one2one ) Rabbit_ USP30 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | USP11, USP20, USP4, USP5, USP42, USP14, USP29, USP25, USP48, USP2, USP47, USP40, USP3, USP1, USP34, USP8, USP21, USP24, USP38, USP32, USP6, USP31, USP50, USP13, USP7, USP43, USP17L4, USP17L11, USP17L27, USP17L22, USP17L30, USP17L17, USP17L26, USP17L25, USP17L12, USP17L10, USP17L28, USP17L1, USP17L5, USP17L24, USP17L21, USP17L3, USP17L29, USP17L18, USP17L13, USP17L15, USP17L7, USP17L23, USP17L2, USP17L20, USP17L8, USP17L19, USP35, USP45, USP33, USP49, USP51, USP19, USP15, USP28, USP9X, USP9Y, USP27X, USP44, USP18, USP10, USP22, USP26, USP16, USP37, USP36 |
| Tissue | NA |
| Tissue Specificity | Expressed in skeletal muscle, pancreas, liver and kidney. {ECO:0000269|PubMed:14715245}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.026667(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5OHK (X-ray 2.34A ) 5OHN (X-ray 3.60A ) 5OHP (X-ray 2.80A ) |
| DBSNP | rs16939904 |
| Subcellular location [CC] | Mitochondrion outer membrane {ECO:0000269|PubMed:18287522, ECO:0000269|PubMed:24896179}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |