| Gene Information | |
|---|---|
| Gene Name | USP3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 520 |
| Protein Names | Ubiquitin carboxyl-terminal hydrolase 3 (EC 3.4.19.12) (Deubiquitinating enzyme 3) (Ubiquitin thioesterase 3) (Ubiquitin-specific-processing protease 3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000140455 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9Y6I4 |
| Gene Card | USP3 |
| Uniprot ID | Q9Y6I4 |
| Pfam | PF00443; PF02148 |
| In ASD | no |
| Allosteric Prediction | yes (0.254917576) |
| Ortholog in Animals | Alpaca_ USP3 ( ortholog_one2one ) Dog_ USP3 ( ortholog_one2one ) GuineaPig_ USP3 ( ortholog_one2one ) Macaque_ USP3 ( ortholog_one2one ) Mouse_ Usp3 ( ortholog_one2one ) Pig_ USP3 ( ortholog_one2one ) Rat_ Usp3 ( ortholog_one2one ) Rabbit_ USP3 ( ortholog_one2one ) |
| Ohnologs | USP21 |
| Paralogs | USP11, USP20, USP4, USP5, USP42, USP14, USP29, USP25, USP48, USP2, USP47, USP40, USP1, USP34, USP8, USP21, USP24, USP38, USP32, USP6, USP31, USP50, USP13, USP7, USP43, USP17L4, USP17L11, USP17L27, USP17L22, USP17L30, USP17L17, USP17L26, USP17L25, USP17L12, USP17L10, USP17L28, USP17L1, USP17L5, USP17L24, USP17L21, USP17L3, USP17L29, USP17L18, USP17L13, USP17L15, USP17L7, USP17L23, USP17L2, USP17L20, USP17L8, USP17L19, USP35, USP45, USP33, USP49, USP51, USP19, USP15, USP28, USP9X, USP9Y, USP27X, USP44, USP18, USP30, USP10, USP22, USP26, USP16, USP37, USP36 |
| Tissue | NA |
| Tissue Specificity | Expressed in all tissues examined, with strongest expression in pancreas. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs34776764 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:17980597}. Note=Localizes preferentially with monoubiquitinated H2A to chromatin. |
| Mouse PG classification | NA |
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