| Gene Information | |
|---|---|
| Gene Name | USP21 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1055 |
| Protein Names | Ubiquitin carboxyl-terminal hydrolase 25 (EC 3.4.19.12) (Deubiquitinating enzyme 25) (USP on chromosome 21) (Ubiquitin thioesterase 25) (Ubiquitin-specific-processing protease 25) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000143258 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9UHP3 |
| Gene Card | USP25 |
| Uniprot ID | Q9UHP3 |
| Pfam | PF00443; PF02809 |
| In ASD | no |
| Allosteric Prediction | no (-0.101121303) |
| Ortholog in Animals | Alpaca_ USP21 ( ortholog_one2one ) Dog_ USP21 ( ortholog_one2one ) GuineaPig_ USP21 ( ortholog_one2one ) Macaque_ USP21 ( ortholog_one2one ) Mouse_ Usp21 ( ortholog_one2one ) Pig_ USP21 ( ortholog_one2one ) Rat_ Usp21 ( ortholog_one2one ) Rabbit_ USP21 ( ortholog_one2one ) |
| Ohnologs | USP2, USP3 |
| Paralogs | USP11, USP20, USP4, USP5, USP42, USP14, USP29, USP25, USP48, USP2, USP47, USP40, USP3, USP1, USP34, USP8, USP24, USP38, USP32, USP6, USP31, USP50, USP13, USP7, USP43, USP17L4, USP17L11, USP17L27, USP17L22, USP17L30, USP17L17, USP17L26, USP17L25, USP17L12, USP17L10, USP17L28, USP17L1, USP17L5, USP17L24, USP17L21, USP17L3, USP17L29, USP17L18, USP17L13, USP17L15, USP17L7, USP17L23, USP17L2, USP17L20, USP17L8, USP17L19, USP35, USP45, USP33, USP49, USP51, USP19, USP15, USP28, USP9X, USP9Y, USP27X, USP44, USP18, USP30, USP10, USP22, USP26, USP16, USP37, USP36 |
| Tissue | NA |
| Tissue Specificity | Isoform USP25a is found in most adult and fetal tissues; expression is moderately high in testis, pancreas, kidney, skeletal muscle, liver, lung, placenta, brain, heart, but very low in peripheral blood, colon, small intestine, ovary, prostate, thymus and spleen. Isoform USP25b is found in all tissues except heart and skeletal muscle. Isoform USP25m is heart and skeletal muscle specific. {ECO:0000269|PubMed:10644437, ECO:0000269|PubMed:11597335}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.010526(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2MUX (NMR - ) 5GP7 (X-ray 1.50A ) 5O71 (X-ray 3.28A ) 6H4J (X-ray 3.07A ) 6H4K (X-ray 2.05A ) 6HEL (X-ray 2.94A ) 6HEM (X-ray 1.72A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:16501887, ECO:0000269|PubMed:19440361}.; [Isoform USP25m]: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Some transient punctuate nuclear location in myotubes during myocyte development. {ECO:0000250}. |
| Mouse PG classification | NA |
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