Gene Information
Gene NameUSP20
OrganismHomo sapiens (Human)
Gene Length914
Protein NamesUbiquitin carboxyl-terminal hydrolase 20 (EC 3.4.19.12) (Deubiquitinating enzyme 20) (Ubiquitin thioesterase 20) (Ubiquitin-specific-processing protease 20) (VHL-interacting deubiquitinating enzyme 2) (hVDU2)
Target Nameubiquitin carboxyl-terminal hydrolase 20
Target TypePreclinical target
Gene Age645 ( ENSG00000136878 )
Evolutionary StageEukaryota
AlphaFoldDBQ9Y2K6
Gene CardUSP20
Uniprot IDQ9Y2K6
PfamPF06337; PF00443; PF02148
In ASDno
Allosteric Predictionyes (0.031693493)
Ortholog in AnimalsAlpaca_ USP20 ( ortholog_one2one )
Dog_ USP20 ( ortholog_one2one )
GuineaPig_ USP20 ( ortholog_one2one )
Macaque_ USP20 ( ortholog_one2one )
Mouse_ Usp20 ( ortholog_one2one )
Pig_ USP20 ( ortholog_one2one )
Rat_ Usp20 ( ortholog_one2one )
Rabbit_ USP20 ( ortholog_one2one )
OhnologsUSP33
ParalogsUSP11, USP4, USP5, USP42, USP14, USP29, USP25, USP48, USP2, USP47, USP40, USP3, USP1, USP34, USP8, USP21, USP24, USP38, USP32, USP6, USP31, USP50, USP13, USP7, USP43, USP17L4, USP17L11, USP17L27, USP17L22, USP17L30, USP17L17, USP17L26, USP17L25, USP17L12, USP17L10, USP17L28, USP17L1, USP17L5, USP17L24, USP17L21, USP17L3, USP17L29, USP17L18, USP17L13, USP17L15, USP17L7, USP17L23, USP17L2, USP17L20, USP17L8, USP17L19, USP35, USP45, USP33, USP49, USP51, USP19, USP15, USP28, USP9X, USP9Y, USP27X, USP44, USP18, USP30, USP10, USP22, USP26, USP16, USP37, USP36
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 6KCZ  (NMR  -  ) 
DBSNP rs36086252  rs36055332 
Subcellular location [CC]Cytoplasm, perinuclear region {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:23486064}. Note=According to PubMed:12865408, it localizes in the endoplasmic reticulum;
however the relevance of such result is unclear.
Mouse PG classificationNA
click here to return to the previous page