| Gene Information | |
|---|---|
| Gene Name | SPEF1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 236 |
| Protein Names | Sperm flagellar protein 1 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000101222 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9Y4P9 |
| Gene Card | SPEF1 |
| Uniprot ID | Q9Y4P9 |
| Pfam | PF06294 |
| In ASD | no |
| Allosteric Prediction | no (-1.65240706) |
| Ortholog in Animals | Alpaca_ SPEF1 ( ortholog_one2one ) Dog_ SPEF1 ( ortholog_one2one ) GuineaPig_ SPEF1 ( ortholog_one2one ) Mouse_ Spef1 ( ortholog_one2one ) Pig_ SPEF1 ( ortholog_one2one ) Rat_ Spef1 ( ortholog_one2one ) Rabbit_ SPEF1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SPATA4 |
| Tissue | caudate.nucleus, cerebral.cortex, hippocampus, nucleus.accumbens, putamen, testis |
| Tissue Specificity | Expressed in the intestinal epithelial cells (at protein level). {ECO:0000269|PubMed:31473225}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2EE7 (NMR - ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:31473225}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q99JL1}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q0IH24}. Apical cell membrane {ECO:0000269|PubMed:31473225}. Basolateral cell membrane {ECO:0000269|PubMed:31473225}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000269|PubMed:31473225}. Cell projection, microvillus {ECO:0000269|PubMed:31473225}. Cell projection, lamellipodium {ECO:0000269|PubMed:31473225}. Cell projection, filopodium {ECO:0000269|PubMed:31473225}. Note=Present in the tails of developing and epididymal sperm, internal to the fibrous sheath and around the outer dense fibers of the sperm flagellum. Also found at the apical tip of cilia (By similarity). Colocalizes with TJP1 and CGN at sites of cell-cell contact in intestinal epithelial cells (PubMed:31473225). {ECO:0000250|UniProtKB:Q0IH24, ECO:0000269|PubMed:31473225}. |
| Mouse PG classification | NA |
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