| Gene Information | |
|---|---|
| Gene Name | HTR1B |
| Organism | Homo sapiens (Human) |
| Gene Length | 390 |
| Protein Names | 5-hydroxytryptamine receptor 1B (5-HT-1B) (5-HT1B) (S12) (Serotonin 1D beta receptor) (5-HT-1D-beta) (Serotonin receptor 1B) |
| Target Name | 5-hydroxytryptamine receptor 1 |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000135312 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P28222 |
| Gene Card | HTR1B |
| Uniprot ID | P28222 |
| Pfam | PF00001 |
| In ASD | no |
| Allosteric Prediction | yes (1.745299218) |
| Ortholog in Animals | Alpaca_ HTR1B ( ortholog_one2one ) Dog_ HTR1B ( ortholog_one2one ) GuineaPig_ HTR1B ( ortholog_one2one ) Macaque_ HTR1B ( ortholog_one2one ) Mouse_ Htr1b ( ortholog_one2one ) Pig_ HTR1B ( ortholog_one2one ) Rat_ Htr1b ( ortholog_one2one ) Rabbit_ HTR1B ( ortholog_one2one ) |
| Ohnologs | HTR7, ADRA1B, HTR1A, HTR1F, HTR1D |
| Paralogs | HTR1E, HTR1F, HTR5A, HTR7, HTR6, HTR2C, HTR2A, HTR2B |
| Tissue | NA |
| Tissue Specificity | Detected in cerebral artery smooth muscle cells (at protein level). Detected in brain cortex, striatum, amygdala, medulla, hippocampus, caudate nucleus and putamen. {ECO:0000269|PubMed:1348246, ECO:0000269|PubMed:1351684, ECO:0000269|PubMed:15853772}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002657(Rat);0.028571(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4IAQ (X-ray 2.80A ) 4IAR (X-ray 2.70A ) 5V54 (X-ray 3.90A ) 6G79 (EM 3.78A ) 7C61 (X-ray 3.00A ) |
| DBSNP | rs130060 rs130061 rs130063 rs130064 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:10452531, ECO:0000269|PubMed:1315531, ECO:0000269|PubMed:1328844, ECO:0000269|PubMed:1348246, ECO:0000269|PubMed:1351684, ECO:0000269|PubMed:1559993, ECO:0000269|PubMed:1565658, ECO:0000269|PubMed:1610347, ECO:0000269|PubMed:23519210, ECO:0000269|PubMed:23519215}; Multi-pass membrane protein {ECO:0000269|PubMed:10452531, ECO:0000269|PubMed:1315531, ECO:0000269|PubMed:1328844, ECO:0000269|PubMed:1348246, ECO:0000269|PubMed:1351684, ECO:0000269|PubMed:1559993, ECO:0000269|PubMed:1565658, ECO:0000269|PubMed:1610347, ECO:0000269|PubMed:23519210, ECO:0000269|PubMed:23519215}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |