| Gene Information | |
|---|---|
| Gene Name | NHLRC1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 395 |
| Protein Names | E3 ubiquitin-protein ligase NHLRC1 (EC 2.3.2.27) (Malin) (NHL repeat-containing protein 1) (RING-type E3 ubiquitin transferase NHLRC1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000187566 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q6VVB1 |
| Gene Card | NHLRC1 |
| Uniprot ID | Q6VVB1 |
| Pfam | PF14634 |
| In ASD | no |
| Allosteric Prediction | no (-0.35400114) |
| Ortholog in Animals | Alpaca_ NHLRC1 ( ortholog_one2one ) Dog_ NHLRC1 ( ortholog_one2one ) GuineaPig_ NHLRC1 ( ortholog_one2one ) Macaque_ NHLRC1 ( ortholog_one2one ) Mouse_ Nhlrc1 ( ortholog_one2one ) Rat_ Nhlrc1 ( ortholog_one2one ) Rabbit_ NHLRC1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in brain, cerebellum, spinal cord, medulla, heart, liver, skeletal muscle and pancreas. {ECO:0000269|PubMed:12958597}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);0.002990(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs28940575 rs757759398 rs1193718748 rs779507031 rs28940576 rs10949483 rs950907157 rs769301934 rs200595273 rs121917876 rs879745047 rs757858146 rs137852859 |
| Subcellular location [CC] | Endoplasmic reticulum. Nucleus. Note=Localizes at the endoplasmic reticulum and, to a lesser extent, in the nucleus. |
| Mouse PG classification | HPG |
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