| Gene Information | |
|---|---|
| Gene Name | USP14 |
| Organism | Homo sapiens (Human) |
| Gene Length | 494 |
| Protein Names | Ubiquitin carboxyl-terminal hydrolase 14 (EC 3.4.19.12) (Deubiquitinating enzyme 14) (Ubiquitin thioesterase 14) (Ubiquitin-specific-processing protease 14) |
| Target Name | ubiquitin carboxyl-terminal hydrolase 14 |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000101557 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P54578 |
| Gene Card | USP14 |
| Uniprot ID | P54578 |
| Pfam | PF00443 |
| In ASD | yes |
| Allosteric Prediction | yes (0.999666332) |
| Ortholog in Animals | Alpaca_ USP14 ( ortholog_one2one ) Dog_ USP14 ( ortholog_one2one ) GuineaPig_ USP14 ( ortholog_one2one ) Macaque_ USP14 ( ortholog_one2one ) Mouse_ Usp14 ( ortholog_one2one ) Pig_ USP14 ( ortholog_one2one ) Rat_ Usp14 ( ortholog_one2one ) Rabbit_ USP14 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | USP11, USP20, USP4, USP5, USP42, USP29, USP25, USP48, USP2, USP47, USP40, USP3, USP1, USP34, USP8, USP21, USP24, USP38, USP32, USP6, USP31, USP50, USP13, USP7, USP43, USP17L4, USP17L11, USP17L27, USP17L22, USP17L30, USP17L17, USP17L26, USP17L25, USP17L12, USP17L10, USP17L28, USP17L1, USP17L5, USP17L24, USP17L21, USP17L3, USP17L29, USP17L18, USP17L13, USP17L15, USP17L7, USP17L23, USP17L2, USP17L20, USP17L8, USP17L19, USP35, USP45, USP33, USP49, USP51, USP19, USP15, USP28, USP9X, USP9Y, USP27X, USP44, USP18, USP30, USP10, USP22, USP26, USP16, USP37, USP36 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | 0.056905(Chimpanzee);0.125683(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2AYN (X-ray 3.20A ) 2AYO (X-ray 3.50A ) 5GJQ (EM 4.50A ) 6IIK (X-ray 1.97A ) 6IIL (X-ray 2.20A ) 6IIM (X-ray 2.21A ) 6IIN (X-ray 2.53A ) 6LVS (X-ray 2.73A ) 7W37 (EM 3.00A ) 7W38 (EM 3.10A ) 7W39 (EM 3.20A ) 7W3A (EM 3.50A ) 7W3B (EM 3.60A ) 7W3C (EM 3.40A ) 7W3F (EM 3.30A ) 7W3G (EM 3.20A ) 7W3H (EM 3.20A ) 7W3I (EM 3.50A ) 7W3J (EM 3.50A ) 7W3K (EM 3.60A ) 7W3M (EM 3.50A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:19106094}. Cell membrane {ECO:0000269|PubMed:19106094}; Peripheral membrane protein {ECO:0000269|PubMed:19106094}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |