Gene Information
Gene NameUSP10
OrganismHomo sapiens (Human)
Gene Length798
Protein NamesUbiquitin carboxyl-terminal hydrolase 10 (EC 3.4.19.12) (Deubiquitinating enzyme 10) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10)
Target Nameubiquitin carboxyl-terminal hydrolase 10
Target TypePreclinical target
Gene Age645 ( ENSG00000103194 )
Evolutionary StageEukaryota
AlphaFoldDBQ14694
Gene CardUSP10
Uniprot IDQ14694
PfamPF07145; PF00443
In ASDno
Allosteric Predictionno (-0.306214493)
Ortholog in AnimalsAlpaca_ USP10 ( ortholog_one2one )
Dog_ USP10 ( ortholog_one2one )
GuineaPig_ USP10 ( ortholog_one2one )
Macaque_ USP10 ( ortholog_one2one )
Mouse_ Usp10 ( ortholog_one2one )
Pig_ USP10 ( ortholog_one2one )
Rat_ Usp10 ( ortholog_one2one )
Rabbit_ USP10 ( ortholog_one2one )
OhnologsNA
ParalogsUSP11, USP20, USP4, USP5, USP42, USP14, USP29, USP25, USP48, USP2, USP47, USP40, USP3, USP1, USP34, USP8, USP21, USP24, USP38, USP32, USP6, USP31, USP50, USP13, USP7, USP43, USP17L4, USP17L11, USP17L27, USP17L22, USP17L30, USP17L17, USP17L26, USP17L25, USP17L12, USP17L10, USP17L28, USP17L1, USP17L5, USP17L24, USP17L21, USP17L3, USP17L29, USP17L18, USP17L13, USP17L15, USP17L7, USP17L23, USP17L2, USP17L20, USP17L8, USP17L19, USP35, USP45, USP33, USP49, USP51, USP19, USP15, USP28, USP9X, USP9Y, USP27X, USP44, USP18, USP30, USP22, USP26, USP16, USP37, USP36
TissueNA
Tissue SpecificityWidely expressed. {ECO:0000269|PubMed:11439350}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs1862792  rs2326391  rs1812061 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:20096447}. Nucleus {ECO:0000269|PubMed:20096447, ECO:0000269|PubMed:24845384}. Early endosome {ECO:0000269|PubMed:19398555}. Note=Cytoplasmic in normal conditions (PubMed:20096447). After DNA damage, translocates to the nucleus following phosphorylation by ATM (PubMed:20096447). {ECO:0000269|PubMed:20096447}.
Mouse PG classificationNA
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