| Gene Information | |
|---|---|
| Gene Name | USP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 785 |
| Protein Names | Ubiquitin carboxyl-terminal hydrolase 1 (EC 3.4.19.12) (Deubiquitinating enzyme 1) (hUBP) (Ubiquitin thioesterase 1) (Ubiquitin-specific-processing protease 1) [Cleaved into: Ubiquitin carboxyl-terminal hydrolase 1, N-terminal fragment] |
| Target Name | deubiquitinating enzyme 1 |
| Target Type | Literature-reported target |
| Gene Age | 645 ( ENSG00000162607 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O94782 |
| Gene Card | USP1 |
| Uniprot ID | O94782 |
| Pfam | PF00443 |
| In ASD | no |
| Allosteric Prediction | no (-0.291075503) |
| Ortholog in Animals | Alpaca_ USP1 ( ortholog_one2one ) Dog_ USP1 ( ortholog_one2one ) GuineaPig_ USP1 ( ortholog_one2one ) Macaque_ USP1 ( ortholog_one2one ) Mouse_ Usp1 ( ortholog_one2one ) Pig_ USP1 ( ortholog_one2one ) Rat_ Usp1 ( ortholog_one2one ) Rabbit_ USP1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | USP11, USP20, USP4, USP5, USP42, USP14, USP29, USP25, USP48, USP2, USP47, USP40, USP3, USP34, USP8, USP21, USP24, USP38, USP32, USP6, USP31, USP50, USP13, USP7, USP43, USP17L4, USP17L11, USP17L27, USP17L22, USP17L30, USP17L17, USP17L26, USP17L25, USP17L12, USP17L10, USP17L28, USP17L1, USP17L5, USP17L24, USP17L21, USP17L3, USP17L29, USP17L18, USP17L13, USP17L15, USP17L7, USP17L23, USP17L2, USP17L20, USP17L8, USP17L19, USP35, USP45, USP33, USP49, USP51, USP19, USP15, USP28, USP9X, USP9Y, USP27X, USP44, USP18, USP30, USP10, USP22, USP26, USP16, USP37, USP36 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.025(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 6DO5 (X-ray 2.50A ) 7AY0 (X-ray 3.60A ) 7AY1 (EM 3.70A ) 7AY2 (X-ray 3.20A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:15694335}. |
| Mouse PG classification | NA |
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