| Gene Information | |
|---|---|
| Gene Name | GOT1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 413 |
| Protein Names | Aspartate aminotransferase, cytoplasmic (cAspAT) (EC 2.6.1.1) (EC 2.6.1.3) (Cysteine aminotransferase, cytoplasmic) (Cysteine transaminase, cytoplasmic) (cCAT) (Glutamate oxaloacetate transaminase 1) (Transaminase A) |
| Target Name | aspartate aminotransferase, cytoplasmic |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000120053 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P17174 |
| Gene Card | GOT1 |
| Uniprot ID | P17174 |
| Pfam | PF00155 |
| In ASD | yes |
| Allosteric Prediction | yes (0.795334963) |
| Ortholog in Animals | Alpaca_ GOT1 ( ortholog_one2one ) Dog_ GOT1 ( ortholog_one2one ) GuineaPig_ GOT1 ( ortholog_one2one ) Macaque_ GOT1 ( ortholog_one2one ) Mouse_ Got1 ( ortholog_one2one ) Pig_ GOT1 ( ortholog_one2one ) Rat_ Got1 ( ortholog_one2one ) Rabbit_ GOT1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | GOT1L1, GOT2 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3II0 (X-ray 2.05A ) 3WZF (X-ray 2.99A ) 6DNA (X-ray 3.00A ) 6DNB (X-ray 1.70A ) 6DND (X-ray 2.10A ) 6LIG (X-ray 2.62A ) |
| DBSNP | rs749913156 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:1974457}. |
| Mouse PG classification | NA |
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