| Gene Information | |
|---|---|
| Gene Name | UPF3A |
| Organism | Homo sapiens (Human) |
| Gene Length | 476 |
| Protein Names | Regulator of nonsense transcripts 3A (Nonsense mRNA reducing factor 3A) (Up-frameshift suppressor 3 homolog A) (hUpf3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000169062 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9H1J1 |
| Gene Card | UPF3A |
| Uniprot ID | Q9H1J1 |
| Pfam | PF03467 |
| In ASD | no |
| Allosteric Prediction | no (-0.915033379) |
| Ortholog in Animals | Alpaca_ UPF3A ( ortholog_one2one ) GuineaPig_ UPF3A ( ortholog_one2one ) Macaque_ UPF3A ( ortholog_one2one ) Mouse_ Upf3a ( ortholog_one2one ) Pig_ UPF3A ( ortholog_one2one ) Rat_ Upf3a ( ortholog_one2one ) |
| Ohnologs | UPF3B |
| Paralogs | UPF3B |
| Tissue | NA |
| Tissue Specificity | Isoform 1 is strongly expressed in testis, uterus, muscle, fetal brain and spinal cord. Isoform 2 is strongly expressed in fetal brain and spinal cord. {ECO:0000269|PubMed:11113196}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);0.001899(Rat);0.054545(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2L08 (NMR - ) 7QG6 (X-ray 2.95A ) |
| DBSNP | rs3752105 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:11163187}. Cytoplasm {ECO:0000269|PubMed:11163187}. Note=Shuttling between the nucleus and the cytoplasm. {ECO:0000269|PubMed:11163187}. |
| Mouse PG classification | NA |
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