| Gene Information | |
|---|---|
| Gene Name | UPAR |
| Organism | Homo sapiens (Human) |
| Gene Length | 335 |
| Protein Names | Urokinase plasminogen activator surface receptor (U-PAR) (uPAR) (Monocyte activation antigen Mo3) (CD antigen CD87) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q03405 |
| Gene Card | PLAUR |
| Uniprot ID | Q03405 |
| Pfam | PF00021 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1YWH (X-ray 2.70A ) 2FD6 (X-ray 1.90A ) 2I9B (X-ray 2.80A ) 3BT1 (X-ray 2.80A ) 3BT2 (X-ray 2.50A ) 3U73 (X-ray 3.19A ) 3U74 (X-ray 2.39A ) 4K24 (X-ray 4.50A ) 4QTI (X-ray 3.00A ) 7E17 (X-ray 2.96A ) 7V63 (X-ray 2.91A ) |
| DBSNP | rs4251813 rs399145 rs4251878 rs2302524 rs4251921 rs16976608 rs4760 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:12376466}. Cell projection, invadopodium membrane {ECO:0000269|PubMed:12376466}. Note=Colocalized with FAP (seprase) preferentially at the cell surface of invadopodia membrane in a cytoskeleton-, integrin- and vitronectin-dependent manner. {ECO:0000269|PubMed:12376466}.; [Isoform 1]: Cell membrane {ECO:0000250|UniProtKB:P49616}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P49616}.; [Isoform 2]: Secreted {ECO:0000250|UniProtKB:P49616}. |
| Mouse PG classification | NA |
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