| Gene Information | |
|---|---|
| Gene Name | HDAC7 |
| Organism | Homo sapiens (Human) |
| Gene Length | 952 |
| Protein Names | Histone deacetylase 7 (HD7) (EC 3.5.1.98) (Histone deacetylase 7A) (HD7a) |
| Target Name | histone deacetylase 7 |
| Target Type | Patented-recorded target |
| Gene Age | 454 ( ENSG00000061273 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q8WUI4 |
| Gene Card | HDAC7 |
| Uniprot ID | Q8WUI4 |
| Pfam | PF00850 |
| In ASD | yes |
| Allosteric Prediction | yes (1.232642907) |
| Ortholog in Animals | Alpaca_ HDAC7 ( ortholog_one2one ) Dog_ HDAC7 ( ortholog_one2one ) GuineaPig_ HDAC7 ( ortholog_one2one ) Macaque_ HDAC7 ( ortholog_one2one ) Mouse_ Hdac7 ( ortholog_one2one ) Pig_ HDAC7 ( ortholog_one2one ) Rat_ Hdac7 ( ortholog_one2one ) |
| Ohnologs | HDAC5, HDAC9, HDAC4 |
| Paralogs | HDAC4, HDAC11, HDAC8, HDAC3, HDAC6, HDAC10, HDAC2, HDAC1, HDAC5, HDAC9 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3C0Y (X-ray 2.10A ) 3C0Z (X-ray 2.10A ) 3C10 (X-ray 2.00A ) 3ZNR (X-ray 2.40A ) 3ZNS (X-ray 2.45A ) |
| DBSNP | rs1165948169 |
| Subcellular location [CC] | Nucleus. Cytoplasm. Note=In the nucleus, it associates with distinct subnuclear dot-like structures. Shuttles between the nucleus and the cytoplasm. Treatment with EDN1 results in shuttling from the nucleus to the perinuclear region. The export to cytoplasm depends on the interaction with the 14-3-3 protein YWHAE and is due to its phosphorylation. |
| Mouse PG classification | NA |
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