| Gene Information | |
|---|---|
| Gene Name | LY75 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1722 |
| Protein Names | Lymphocyte antigen 75 (Ly-75) (C-type lectin domain family 13 member B) (DEC-205) (gp200-MR6) (CD antigen CD205) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000054219 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | O60449 |
| Gene Card | LY75 |
| Uniprot ID | O60449 |
| Pfam | PF00040; PF00059 |
| In ASD | no |
| Allosteric Prediction | no (-0.406833812) |
| Ortholog in Animals | Alpaca_ LY75 ( ortholog_one2one ) Dog_ LY75 ( ortholog_one2one ) GuineaPig_ LY75 ( ortholog_one2one ) Mouse_ Ly75 ( ortholog_one2one ) Pig_ LY75 ( ortholog_one2one ) Rat_ Ly75 ( ortholog_one2one ) Rabbit_ LY75 ( ortholog_one2one ) |
| Ohnologs | MRC2 |
| Paralogs | PLA2R1, MRC2, MRC1, CD302 |
| Tissue | NA |
| Tissue Specificity | Expressed in spleen, thymus, colon and peripheral blood lymphocytes. Detected in myeloid and B-lymphoid cell lines. Isoform 2 and isoform 3 are expressed in malignant Hodgkin lymphoma cells called Hodgkin and Reed-Sternberg (HRS) cells. {ECO:0000269|PubMed:12824192, ECO:0000269|PubMed:9862343}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7JPT (EM 3.20A ) 7JPU (EM 5.00A ) |
| DBSNP | rs35284483 rs2271381 rs2729709 rs34020639 rs1397706 rs3951216 rs3815875 rs2303549 rs12692566 rs17827158 rs2059696 rs35941588 |
| Subcellular location [CC] | Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. |
| Mouse PG classification | NA |
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