| Gene Information | |
|---|---|
| Gene Name | SGK3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 496 |
| Protein Names | Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Cytokine-independent survival kinase) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid-regulated kinase-like) |
| Target Name | serine/threonine-protein kinase sgk3 |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000104205 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q96BR1 |
| Gene Card | SGK3 |
| Uniprot ID | Q96BR1 |
| Pfam | PF00069; PF00433; PF00787 |
| In ASD | no |
| Allosteric Prediction | yes (0.440399079) |
| Ortholog in Animals | Alpaca_ SGK3 ( ortholog_one2one ) Dog_ SGK3 ( ortholog_one2one ) GuineaPig_ SGK3 ( ortholog_one2one ) Macaque_ SGK3 ( ortholog_one2one ) Mouse_ Sgk3 ( ortholog_one2one ) Pig_ SGK3 ( ortholog_one2one ) Rat_ Sgk3 ( ortholog_one2one ) Rabbit_ SGK3 ( ortholog_one2one ) |
| Ohnologs | SGK2, SGK1 |
| Paralogs | SGK2, STK32B, MAST3, STK32A, MAST2, LATS2, SGK1, MAST4, LATS1, STK32C, MAST1, DMPK, MASTL |
| Tissue | NA |
| Tissue Specificity | Expressed in most tissues with highest levels in pancreas, kidney liver, heart and brain and lower levels in lung, placenta and skeletal muscle. Expression is higher in ER-positive breast tumors than ER-negative breast tumors. {ECO:0000269|PubMed:21084382}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.066667(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 6EDX (X-ray 2.01A ) |
| DBSNP | rs750700898 |
| Subcellular location [CC] | Cytoplasmic vesicle {ECO:0000250}. Early endosome. Recycling endosome. Note=Endosomal localization is a prerequisite for complete kinase activity. It is essential for its colocalization with the kinase responsible for phosphorylating Ser-486 thus allowing PDPK1 phosphorylation of Thr-320 resulting in complete activation of SGK3. Localized in vesicle-like structures and in the early endosome. Colocalizes with SLC9A3/NHE3 in the recycling endosomes. |
| Mouse PG classification | NA |
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