| Gene Information | |
|---|---|
| Gene Name | CTSD |
| Organism | Homo sapiens (Human) |
| Gene Length | 412 |
| Protein Names | Cathepsin D (EC 3.4.23.5) [Cleaved into: Cathepsin D light chain; Cathepsin D heavy chain] |
| Target Name | cathepsin d |
| Target Type | Clinical trial target |
| Gene Age | 1488 ( ENSG00000117984 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P07339 |
| Gene Card | CTSD |
| Uniprot ID | P07339 |
| Pfam | PF07966; PF00026 |
| In ASD | no |
| Allosteric Prediction | yes (1.159495289) |
| Ortholog in Animals | Dog_ CTSD ( ortholog_one2one ) GuineaPig_ CTSD ( ortholog_one2one ) Macaque_ CTSD ( ortholog_one2one ) Mouse_ Ctsd ( ortholog_one2one ) Pig_ CTSD ( ortholog_one2one ) Rat_ Ctsd ( ortholog_one2one ) |
| Ohnologs | NAPSA, REN, CTSE |
| Paralogs | PGC, BACE2, REN, CTSE, BACE1, NAPSA, PGA5, PGA4, PGA3 |
| Tissue | NA |
| Tissue Specificity | Expressed in the aorta extracellular space (at protein level) (PubMed:20551380). Expressed in liver (at protein level) (PubMed:1426530). {ECO:0000269|PubMed:1426530, ECO:0000269|PubMed:20551380}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1LYA (X-ray 2.50A ) 1LYB (X-ray 2.50A ) 1LYW (X-ray 2.50A ) 4OBZ (X-ray 2.90A ) 4OC6 (X-ray 2.64A ) 4OD9 (X-ray 1.90A ) |
| DBSNP | rs17571 rs121912789 rs147278302 rs121912790 |
| Subcellular location [CC] | Lysosome. Melanosome. Secreted, extracellular space. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In aortic samples, detected as an extracellular protein loosely bound to the matrix (PubMed:20551380). {ECO:0000269|PubMed:20551380}. |
| Mouse PG classification | NA |
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