| Gene Information | |
|---|---|
| Gene Name | GUCA1B |
| Organism | Homo sapiens (Human) |
| Gene Length | 200 |
| Protein Names | Guanylyl cyclase-activating protein 2 (GCAP 2) (Guanylate cyclase activator 1B) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000112599 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9UMX6 |
| Gene Card | GUCA1B |
| Uniprot ID | Q9UMX6 |
| Pfam | PF13202; PF13499 |
| In ASD | no |
| Allosteric Prediction | no (-0.426071234) |
| Ortholog in Animals | Alpaca_ GUCA1B ( ortholog_one2one ) Dog_ GUCA1B ( ortholog_one2one ) GuineaPig_ GUCA1B ( ortholog_one2one ) Macaque_ GUCA1B ( ortholog_one2many ) Mouse_ Guca1b ( ortholog_one2one ) Pig_ GUCA1B ( ortholog_one2one ) Rat_ Guca1b ( ortholog_one2one ) Rabbit_ GUCA1B ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | KCNIP4, KCNIP2, VSNL1, KCNIP1, HPCAL1, NCS1, KCNIP3, GUCA1C, GUCA1A, RCVRN, CLXN, NCALD, HPCAL4, HPCA |
| Tissue | NA |
| Tissue Specificity | In the retina, it is expressed in cone and rod photoreceptor cells. {ECO:0000269|PubMed:9620085}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs139923590 rs121909124 |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:P51177}; Lipid-anchor {ECO:0000250|UniProtKB:P51177}. Photoreceptor inner segment {ECO:0000269|PubMed:9620085}. Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:9620085}. Note=Subcellular location is not affected by light or dark conditions. {ECO:0000250|UniProtKB:Q8VBV8}. |
| Mouse PG classification | NA |
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