| Gene Information | |
|---|---|
| Gene Name | UNQ5800/PRO19607/PRO21344 |
| Organism | Homo sapiens (Human) |
| Gene Length | 298 |
| Protein Names | Baculoviral IAP repeat-containing protein 7 (EC 2.3.2.27) (Kidney inhibitor of apoptosis protein) (KIAP) (Livin) (Melanoma inhibitor of apoptosis protein) (ML-IAP) (RING finger protein 50) (RING-type E3 ubiquitin transferase BIRC7) [Cleaved into: Baculoviral IAP repeat-containing protein 7 30kDa subunit (Truncated livin) (p30-Livin) (tLivin)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q96CA5 |
| Gene Card | BIRC7 |
| Uniprot ID | Q96CA5 |
| Pfam | PF00653 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Isoform 1 and isoform 2 are expressed at very low levels or not detectable in most adult tissues. Detected in adult heart, placenta, lung, lymph node, spleen and ovary, and in several carcinoma cell lines. Isoform 2 is detected in fetal kidney, heart and spleen, and at lower levels in adult brain, skeletal muscle and peripheral blood leukocytes. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);0.001516(Rat);0.058824(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1OXN (X-ray 2.20A ) 1OXQ (X-ray 2.30A ) 1OY7 (X-ray 2.70A ) 1TW6 (X-ray 1.71A ) 2I3H (X-ray 1.62A ) 2I3I (X-ray 2.30A ) 3F7G (X-ray 2.30A ) 3F7H (X-ray 1.80A ) 3F7I (X-ray 1.90A ) 3GT9 (X-ray 1.70A ) 3GTA (X-ray 1.70A ) 3UW5 (X-ray 1.71A ) 4AUQ (X-ray 2.18A ) |
| DBSNP | rs1077019 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:17294084}. Cytoplasm {ECO:0000269|PubMed:17294084}. Golgi apparatus {ECO:0000269|PubMed:17294084}. Note=Nuclear, and in a filamentous pattern throughout the cytoplasm. Full-length livin is detected exclusively in the cytoplasm, whereas the truncated form (tLivin) is found in the peri-nuclear region with marked localization to the Golgi apparatus; the accumulation of tLivin in the nucleus shows positive correlation with the increase in apoptosis. |
| Mouse PG classification | NA |
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