| Gene Information | |
|---|---|
| Gene Name | UNQ540/PRO1083 |
| Organism | Homo sapiens (Human) |
| Gene Length | 693 |
| Protein Names | Adhesion G-protein coupled receptor G1 (G-protein coupled receptor 56) (Protein TM7XN1) [Cleaved into: ADGRG1 N-terminal fragment (ADGRG1 NT) (GPR56 N-terminal fragment) (GPR56 NT) (GPR56(N)) (GPR56 extracellular subunit) (GPR56 subunit alpha); ADGRG1 C-terminal fragment (ADGRG1 CT) (GPR56 C-terminal fragment) (GPR56 CT) (GPR56(C)) (GPR56 seven-transmembrane subunit) (GPR56 7TM) (GPR56 subunit beta)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9Y653 |
| Gene Card | ADGRG1 |
| Uniprot ID | Q9Y653 |
| Pfam | PF00002; PF18619; PF01825; PF18587 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely distributed with highest levels found in thyroid gland, brain and heart. Expressed in a great number of tumor cells. Expression is down-regulated in different tumors from highly metastatic cells. {ECO:0000269|PubMed:16757564}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 7SF8 (EM 2.70A ) |
| DBSNP | rs764367185 rs121908462 rs121908466 rs121908465 rs1801257 rs1801255 rs121908463 rs17379472 rs556518689 rs16958679 rs121908464 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:21349848, ECO:0000269|PubMed:24949629}; Multi-pass membrane protein {ECO:0000255}.; [ADGRG1 N-terminal fragment]: Secreted {ECO:0000269|PubMed:21349848}.; [ADGRG1 C-terminal fragment]: Membrane raft {ECO:0000269|PubMed:24949629}. Note=Interaction with its ligand COL3A1 leads to the release of ADGRG1 NT from the membrane and triggers the association of ADGRG1 CT with lipid rafts. {ECO:0000269|PubMed:24949629}. |
| Mouse PG classification | NA |
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