| Gene Information | |
|---|---|
| Gene Name | ENPP2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 863 |
| Protein Names | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (E-NPP 2) (EC 3.1.4.39) (Autotaxin) (Extracellular lysophospholipase D) (LysoPLD) |
| Target Name | extracellular lysophospholipase d |
| Target Type | Patented-recorded target |
| Gene Age | 1488 ( ENSG00000136960 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q13822 |
| Gene Card | ENPP2 |
| Uniprot ID | Q13822 |
| Pfam | PF01223; PF01663; PF01033 |
| In ASD | yes |
| Allosteric Prediction | yes (0.175014429) |
| Ortholog in Animals | Alpaca_ ENPP2 ( ortholog_one2one ) Dog_ ENPP2 ( ortholog_one2one ) GuineaPig_ ENPP2 ( ortholog_one2one ) Macaque_ ENPP2 ( ortholog_one2one ) Mouse_ Enpp2 ( ortholog_one2one ) Pig_ ENPP2 ( ortholog_one2one ) Rat_ Enpp2 ( ortholog_one2one ) Rabbit_ ENPP2 ( ortholog_one2one ) |
| Ohnologs | ENPP3, ENPP1 |
| Paralogs | ENPP4, ENPP5, ENPP6, ENPP7, ENPP1, ENPP3 |
| Tissue | NA |
| Tissue Specificity | Detected in blood plasma (at protein level) (PubMed:12176993, PubMed:26371182). Predominantly expressed in brain, placenta, ovary, and small intestine. Expressed in a number of carcinomas such as hepatocellular and prostate carcinoma, neuroblastoma and non-small-cell lung cancer. Expressed in body fluids such as plasma, cerebral spinal fluid (CSF), saliva, follicular and amniotic fluids. Not detected in leukocytes. Isoform 1 is more highly expressed in peripheral tissues than in the central nervous system (CNS). Adipocytes only express isoform 1. Isoform 3 is more highly expressed in the brain than in peripheral tissues. {ECO:0000269|PubMed:12176993, ECO:0000269|PubMed:18175805, ECO:0000269|PubMed:26371182, ECO:0000269|PubMed:8579579, ECO:0000269|PubMed:8586446}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4ZG6 (X-ray 1.80A ) 4ZG7 (X-ray 1.75A ) 4ZG9 (X-ray 2.95A ) 4ZGA (X-ray 2.60A ) 5KXA (X-ray 2.59A ) 5M7M (X-ray 2.70A ) 5MHP (X-ray 2.43A ) |
| DBSNP | rs10283100 rs2289886 rs16892767 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:12176993, ECO:0000269|PubMed:15769751, ECO:0000269|PubMed:1733949, ECO:0000269|PubMed:26371182, ECO:0000269|PubMed:27754931}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |