| Gene Information | |
|---|---|
| Gene Name | UNQ418/PRO852 |
| Organism | Homo sapiens (Human) |
| Gene Length | 518 |
| Protein Names | Beta-secretase 2 (EC 3.4.23.45) (Aspartic-like protease 56 kDa) (Aspartyl protease 1) (ASP1) (Asp 1) (Beta-site amyloid precursor protein cleaving enzyme 2) (Beta-site APP cleaving enzyme 2) (Down region aspartic protease) (DRAP) (Memapsin-1) (Membrane-associated aspartic protease 1) (Theta-secretase) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9Y5Z0 |
| Gene Card | BACE2 |
| Uniprot ID | Q9Y5Z0 |
| Pfam | PF00026 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Brain. Present in neurons within the hippocampus, frontal cortex and temporal cortex (at protein level). Expressed at low levels in most peripheral tissues and at higher levels in colon, kidney, pancreas, placenta, prostate, stomach and trachea. Expressed at low levels in the brain. Found in spinal cord, medulla oblongata, substantia nigra and locus coruleus. Expressed in the ductal epithelium of both normal and malignant prostate. {ECO:0000269|PubMed:10591213, ECO:0000269|PubMed:10677483, ECO:0000269|PubMed:10683441, ECO:0000269|PubMed:10749877, ECO:0000269|PubMed:10838186, ECO:0000269|PubMed:10965118, ECO:0000269|PubMed:11083922}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2EWY (X-ray 3.10A ) 3ZKG (X-ray 1.90A ) 3ZKI (X-ray 2.40A ) 3ZKM (X-ray 1.85A ) 3ZKN (X-ray 2.00A ) 3ZKQ (X-ray 1.51A ) 3ZKS (X-ray 2.11A ) 3ZKX (X-ray 2.37A ) 3ZL7 (X-ray 3.20A ) 3ZLQ (X-ray 2.10A ) 4BEL (X-ray 1.85A ) 4BFB (X-ray 2.21A ) 6JSZ (X-ray 1.53A ) 6UJ0 (X-ray 2.15A ) 6UJ1 (X-ray 3.03A ) 7D5B (X-ray 1.31A ) 7D5U (X-ray 2.04A ) 7F1G (X-ray 1.50A ) 7N4N (X-ray 1.41A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:21907142}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus {ECO:0000269|PubMed:11423558}. Endoplasmic reticulum. Endosome. Melanosome {ECO:0000269|PubMed:23754390}. Note=Colocalizes with PMEL in stage I and II melanosomes. {ECO:0000269|PubMed:23754390}. |
| Mouse PG classification | NA |
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