| Gene Information | |
|---|---|
| Gene Name | ZACN |
| Organism | Homo sapiens (Human) |
| Gene Length | 412 |
| Protein Names | Zinc-activated ligand-gated ion channel (Ligand-gated ion channel zinc-activated 1) (Ligand-gated ion-channel receptor L2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 168 ( ENSG00000186919 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q401N2 |
| Gene Card | ZACN |
| Uniprot ID | Q401N2 |
| Pfam | PF02931 |
| In ASD | yes |
| Allosteric Prediction | no (-0.240379995) |
| Ortholog in Animals | Alpaca_ ZACN ( ortholog_one2one ) Dog_ ZACN ( ortholog_one2one ) Macaque_ ZACN ( ortholog_one2one ) Pig_ ZACN ( ortholog_one2one ) Rabbit_ ZACN ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CHRNB1, GABRR2, CHRNA6, CHRNB4, CHRNA4, GABRQ, HTR3E, CHRNA1, CHRNA3, GABRA5, GLRA2, HTR3B, GLRA1, GABRG3, GABRA2, GABRB3, GABRP, HTR3C, HTR3D, GABRG1, CHRNA7, CHRFAM7A, GABRD, GABRR1, CHRNA5, GABRA6, GABRA4, GLRA3, GABRE, CHRNE, GABRG2, CHRND, CHRNA2, CHRNA10, CHRNA9, GABRA3, HTR3A, CHRNB3, CHRNB2, CHRNG, GABRR3, GABRB2, GABRB1, GABRA1, GLRB |
| Tissue | NA |
| Tissue Specificity | Detected in pancreas, brain, liver, placenta, trachea, kidney, spinal cord, stomach and fetal brain. In the adult brain region expression is detected in the hippocampus, striatum, amygdala and thalamus. {ECO:0000269|PubMed:12381728, ECO:0000269|PubMed:16083862}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2257020 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:16083862}; Multi-pass membrane protein {ECO:0000269|PubMed:16083862}. |
| Mouse PG classification | NA |
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