Gene Information
Gene NameZC3H12A
OrganismHomo sapiens (Human)
Gene Length599
Protein NamesEndoribonuclease ZC3H12A (EC 3.1.-.-) (Monocyte chemotactic protein-induced protein 1) (MCP-induced protein 1) (MCPIP-1) (Regnase-1) (Reg1) (Zinc finger CCCH domain-containing protein 12A)
Target NameNA
Target TypeNA
Gene Age680 ( ENSG00000163874 )
Evolutionary StageEumetazoa
AlphaFoldDBQ5D1E8
Gene CardZC3H12A
Uniprot IDQ5D1E8
PfamPF18561; PF11977; PF18039
In ASDno
Allosteric Predictionno (-0.189972772)
Ortholog in AnimalsAlpaca_ ZC3H12A ( ortholog_one2one )
Dog_ ZC3H12A ( ortholog_one2one )
GuineaPig_ ZC3H12A ( ortholog_one2one )
Macaque_ ZC3H12A ( ortholog_one2one )
Mouse_ Zc3h12a ( ortholog_one2one )
Pig_ ZC3H12A ( ortholog_one2one )
Rat_ Zc3h12a ( ortholog_one2one )
Rabbit_ ZC3H12A ( ortholog_one2one )
OhnologsZC3H12B, ZC3H12C, ZC3H12D
ParalogsN4BP1, ZC3H12B, NYNRIN, ZC3H12C, ZC3H12D, KHNYN
TissueNA
Tissue SpecificityExpressed in heart, placenta, spleen, kidney, liver and lung (PubMed:19909337). Expressed in leukocytes (PubMed:19909337). Expressed in monocyte (PubMed:16574901). {ECO:0000269|PubMed:16574901, ECO:0000269|PubMed:19909337}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 3V32  (X-ray  2.00A  )  3V33  (X-ray  2.00A  )  3V34  (X-ray  2.00A  ) 
DBSNP rs16824179  rs17849897 
Subcellular location [CC]Nucleus {ECO:0000269|PubMed:16574901}. Cytoplasm {ECO:0000269|PubMed:18178554, ECO:0000269|PubMed:19909337, ECO:0000269|PubMed:22055188}. Cytoplasm, P-body {ECO:0000269|PubMed:22055188, ECO:0000269|PubMed:26134560}. Rough endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q5D1E7};
Peripheral membrane protein {ECO:0000250|UniProtKB:Q5D1E7};
Cytoplasmic side {ECO:0000250|UniProtKB:Q5D1E7}. Cytoplasmic granule {ECO:0000250|UniProtKB:Q5D1E7}. Note=Predominantly localized in the cytoplasm. Colocalizes with GW182 on many granule-like structures, probably corresponding to cytoplasmic GW bodies (GWBs), also called processing bodies (P bodies). Colocalizes with calnexin on the surface of the rough endoplasmic reticulum (RER) membrane and with translationally active polysomes (By similarity). Colocalizes with ZC3H12D in cytoplasmic mRNA processing P-body, also known as GW bodies (GWBs) (PubMed:22055188, PubMed:26134560). {ECO:0000269|PubMed:22055188, ECO:0000269|PubMed:26134560}.
Mouse PG classificationNA
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