| Gene Information | |
|---|---|
| Gene Name | UNQ330/PRO526 |
| Organism | Homo sapiens (Human) |
| Gene Length | 473 |
| Protein Names | Reticulon-4 receptor (Nogo receptor) (NgR) (Nogo-66 receptor) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9BZR6 |
| Gene Card | RTN4R |
| Uniprot ID | Q9BZR6 |
| Pfam | PF13855 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widespread in the brain but highest levels in the gray matter. Low levels in heart and kidney; not expressed in oligodendrocytes (white matter). {ECO:0000269|PubMed:12694398}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1OZN (X-ray 1.52A ) 1P8T (X-ray 3.20A ) |
| DBSNP | rs145292678 rs145773589 rs74315508 rs760855779 rs74315509 rs754793885 rs576939822 rs3747073 rs752810777 rs1432033565 rs112151786 rs757507039 rs149231717 rs779384862 rs748655075 rs200119628 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:12426574, ECO:0000269|PubMed:12694398, ECO:0000269|PubMed:12839991, ECO:0000269|PubMed:16712417, ECO:0000269|PubMed:18411262}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:12694398}. Membrane raft {ECO:0000269|PubMed:12694398}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q99PI8}. Cell projection, axon {ECO:0000250|UniProtKB:Q99PI8}. Perikaryon {ECO:0000250|UniProtKB:Q99M75}. Note=Detected along dendrites and axons, close to synapses, but clearly excluded from synapses. {ECO:0000250|UniProtKB:Q99PI8}. |
| Mouse PG classification | NA |
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