| Gene Information | |
|---|---|
| Gene Name | CHEK1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 476 |
| Protein Names | Serine/threonine-protein kinase Chk1 (EC 2.7.11.1) (CHK1 checkpoint homolog) (Cell cycle checkpoint kinase) (Checkpoint kinase-1) |
| Target Name | serine/threonine-protein kinase chk1 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000149554 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O14757 |
| Gene Card | CHEK1 |
| Uniprot ID | O14757 |
| Pfam | PF00069 |
| In ASD | yes |
| Allosteric Prediction | yes (1.082362131) |
| Ortholog in Animals | Alpaca_ CHEK1 ( ortholog_one2one ) Dog_ CHEK1 ( ortholog_one2one ) Macaque_ CHEK1 ( ortholog_one2one ) Mouse_ Chek1 ( ortholog_one2one ) Pig_ CHEK1 ( ortholog_one2one ) Rat_ Chek1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | seminal.vesicle, vas.deferens |
| Tissue Specificity | Expressed ubiquitously with the most abundant expression in thymus, testis, small intestine and colon. {ECO:0000269|PubMed:9278511, ECO:0000269|PubMed:9382850}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002793(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1IA8 (X-ray 1.70A ) 1NVQ (X-ray 2.00A ) 1NVR (X-ray 1.80A ) 1NVS (X-ray 1.80A ) 1ZLT (X-ray 1.74A ) 1ZYS (X-ray 1.70A ) 2AYP (X-ray 2.90A ) 2BR1 (X-ray 2.00A ) 2BRB (X-ray 2.10A ) 2BRG (X-ray 2.10A ) 2BRH (X-ray 2.10A ) 2BRM (X-ray 2.20A ) 2BRN (X-ray 2.80A ) 2BRO (X-ray 2.20A ) 2C3J (X-ray 2.10A ) 2C3K (X-ray 2.60A ) 2C3L (X-ray 2.35A ) 2CGU (X-ray 2.50A ) 2CGV (X-ray 2.60A ) 2CGW (X-ray 2.20A ) 2CGX (X-ray 2.20A ) 2E9N (X-ray 2.50A ) 2E9O (X-ray 2.10A ) 2E9P (X-ray 2.60A ) 2E9U (X-ray 2.00A ) 2E9V (X-ray 2.00A ) 2GDO (X-ray 3.00A ) 2GHG (X-ray 3.50A ) 2HOG (X-ray 1.90A ) 2HXL (X-ray 1.80A ) 2HXQ (X-ray 2.00A ) 2HY0 (X-ray 1.70A ) 2QHM (X-ray 2.00A ) 2QHN (X-ray 1.70A ) 2R0U (X-ray 1.90A ) 2WMQ (X-ray 2.48A ) 2WMR (X-ray 2.43A ) 2WMS (X-ray 2.70A ) 2WMT (X-ray 2.55A ) 2WMU (X-ray 2.60A ) 2WMV (X-ray 2.01A ) 2WMW (X-ray 2.43A ) 2WMX (X-ray 2.45A ) 2X8D (X-ray 1.90A ) 2X8E (X-ray 2.50A ) 2X8I (X-ray 1.92A ) 2XEY (X-ray 2.70A ) 2XEZ (X-ray 2.25A ) 2XF0 (X-ray 2.40A ) 2YDI (X-ray 1.60A ) 2YDJ (X-ray 1.85A ) 2YDK (X-ray 1.90A ) 2YER (X-ray 1.83A ) 2YEX (X-ray 1.30A ) 2YM3 (X-ray 2.01A ) 2YM4 (X-ray 2.35A ) 2YM5 (X-ray 2.03A ) 2YM6 (X-ray 2.01A ) 2YM7 (X-ray 1.81A ) 2YM8 (X-ray 2.07A ) 2YWP (X-ray 2.90A ) 3F9N (X-ray 1.90A ) 3JVR (X-ray 1.76A ) 3JVS (X-ray 1.90A ) 3NLB (X-ray 1.90A ) 3OT3 (X-ray 1.44A ) 3OT8 (X-ray 1.65A ) 3PA3 (X-ray 1.40A ) 3PA4 (X-ray 1.59A ) 3PA5 (X-ray 1.70A ) 3TKH (X-ray 1.79A ) 3TKI (X-ray 1.60A ) 3U9N (X-ray 1.85A ) 4FSM (X-ray 2.30A ) 4FSN (X-ray 2.10A ) 4FSQ (X-ray 2.40A ) 4FSR (X-ray 2.50A ) 4FST (X-ray 1.90A ) 4FSU (X-ray 2.10A ) 4FSW (X-ray 2.30A ) 4FSY (X-ray 2.30A ) 4FSZ (X-ray 2.30A ) 4FT0 (X-ray 2.30A ) 4FT3 (X-ray 2.50A ) 4FT5 (X-ray 2.40A ) 4FT7 (X-ray 2.20A ) 4FT9 (X-ray 2.20A ) 4FTA (X-ray 2.40A ) 4FTC (X-ray 2.00A ) 4FTI (X-ray 2.20A ) 4FTJ (X-ray 2.20A ) 4FTK (X-ray 2.30A ) 4FTL (X-ray 2.50A ) 4FTM (X-ray 1.90A ) 4FTN (X-ray 2.02A ) 4FTO (X-ray 2.10A ) 4FTQ (X-ray 2.00A ) 4FTR (X-ray 2.25A ) 4FTT (X-ray 2.30A ) 4FTU (X-ray 2.10A ) 4GH2 (X-ray 2.03A ) 4HYH (X-ray 1.70A ) 4HYI (X-ray 1.40A ) 4JIK (X-ray 1.90A ) 4QYE (X-ray 2.05A ) 4QYF (X-ray 2.15A ) 4QYG (X-ray 1.75A ) 4QYH (X-ray 1.90A ) 4RVK (X-ray 1.85A ) 4RVL (X-ray 1.85A ) 4RVM (X-ray 1.86A ) 5DLS (X-ray 2.15A ) 5F4N (X-ray 1.91A ) 5OOP (X-ray 1.70A ) 5OOR (X-ray 1.90A ) 5OOT (X-ray 2.10A ) 5OP2 (X-ray 1.90A ) 5OP4 (X-ray 2.00A ) 5OP5 (X-ray 1.90A ) 5OP7 (X-ray 1.80A ) 5OPB (X-ray 1.55A ) 5OPR (X-ray 1.95A ) 5OPS (X-ray 2.00A ) 5OPU (X-ray 1.55A ) 5OPV (X-ray 1.90A ) 5OQ5 (X-ray 1.40A ) 5OQ6 (X-ray 1.95A ) 5OQ7 (X-ray 2.10A ) 5OQ8 (X-ray 2.00A ) 5WI2 (X-ray 2.50A ) 6FC8 (X-ray 1.61A ) 6FCF (X-ray 1.85A ) 6FCK (X-ray 1.90A ) 7AKM (X-ray 1.93A ) 7AKO (X-ray 1.80A ) 7BJD (X-ray 2.00A ) 7BJE (X-ray 1.80A ) 7BJH (X-ray 1.80A ) 7BJJ (X-ray 1.80A ) 7BJM (X-ray 2.30A ) 7BJO (X-ray 2.30A ) 7BJR (X-ray 1.90A ) 7BJX (X-ray 2.40A ) 7BK1 (X-ray 2.00A ) 7BK2 (X-ray 2.00A ) 7BK3 (X-ray 2.00A ) 7BKN (X-ray 2.74A ) 7BKO (X-ray 2.30A ) 7MCK (X-ray 1.65A ) 7SUF (X-ray 1.48A ) 7SUG (X-ray 1.48A ) 7SUH (X-ray 2.46A ) 7SUI (X-ray 2.12A ) 7SUJ (X-ray 2.30A ) |
| DBSNP | rs3731410 rs35817404 rs34097480 rs506504 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12676962, ECO:0000269|PubMed:15311285, ECO:0000269|PubMed:15710331, ECO:0000269|PubMed:9278511}. Chromosome {ECO:0000269|PubMed:12676962, ECO:0000269|PubMed:31316063, ECO:0000269|PubMed:9382850}. Cytoplasm {ECO:0000269|PubMed:12676962}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:15311285}. Note=Nuclear export is mediated at least in part by XPO1/CRM1 (PubMed:12676962). Also localizes to the centrosome specifically during interphase, where it may protect centrosomal CDC2 kinase from inappropriate activation by cytoplasmic CDC25B (PubMed:15311285). Proteolytic cleavage at the C-terminus by SPRTN promotes removal from chromatin (PubMed:31316063). {ECO:0000269|PubMed:12676962, ECO:0000269|PubMed:15311285, ECO:0000269|PubMed:31316063}. |
| Mouse PG classification | NA |
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