| Gene Information | |
|---|---|
| Gene Name | UNQ2976/PRO7455/PRO7476 |
| Organism | Homo sapiens (Human) |
| Gene Length | 213 |
| Protein Names | Sclerostin |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9BQB4 |
| Gene Card | SOST |
| Uniprot ID | Q9BQB4 |
| Pfam | PF05463 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed at low levels with highest levels in bone, cartilage, kidney, liver, bone marrow and primary osteoblasts differentiated for 21 days. Detected in the subendothelial layer of the aortic intima (at protein level). {ECO:0000269|PubMed:20551380}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.08(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2K8P (NMR - ) 3SOV (X-ray 1.27A ) 6L6R (X-ray 3.80A ) |
| DBSNP | rs387907169 rs387907169 |
| Subcellular location [CC] | Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:20551380}. |
| Mouse PG classification | NA |
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