| Gene Information | |
|---|---|
| Gene Name | CYP11B2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 503 |
| Protein Names | Cytochrome P450 11B2, mitochondrial (Aldosterone synthase) (ALDOS) (Aldosterone-synthesizing enzyme) (CYPXIB2) (Corticosterone 18-monooxygenase, CYP11B2) (EC 1.14.15.5) (Cytochrome P-450Aldo) (Cytochrome P-450C18) (Steroid 11-beta-hydroxylase, CYP11B2) (EC 1.14.15.4) (Steroid 18-hydroxylase) |
| Target Name | cytochrome p450 11b2, mitochondrial |
| Target Type | NA |
| Gene Age | 86 ( ENSG00000179142 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P19099 |
| Gene Card | CYP11B2 |
| Uniprot ID | P19099 |
| Pfam | PF00067 |
| In ASD | no |
| Allosteric Prediction | yes (1.120149506) |
| Ortholog in Animals | Macaque_ CYP11B2 ( ortholog_one2one ) |
| Ohnologs | CYP24A1, CYP27A1 |
| Paralogs | CYP11A1, CYP11B1 |
| Tissue | adrenal.gland |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4DVQ (X-ray 2.49A ) 4FDH (X-ray 2.71A ) 4ZGX (X-ray 3.20A ) 6XZ8 (X-ray 3.00A ) 6XZ9 (X-ray 2.77A ) 7M8I (X-ray 2.94A ) 7M8V (X-ray 3.08A ) |
| DBSNP | rs6438 rs6441 rs4539 rs28931609 rs121912978 rs104894072 rs5308 rs4547 rs4537 rs4544 rs5312 rs61757294 rs5315 rs4545 rs72554627 rs5317 rs72554626 |
| Subcellular location [CC] | Mitochondrion inner membrane {ECO:0000250|UniProtKB:P14137}; Peripheral membrane protein {ECO:0000250|UniProtKB:P14137}. |
| Mouse PG classification | NA |
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