Gene Information
Gene NameMALT1
OrganismHomo sapiens (Human)
Gene Length824
Protein NamesMucosa-associated lymphoid tissue lymphoma translocation protein 1 (EC 3.4.22.-) (MALT lymphoma-associated translocation) (Paracaspase)
Target Namemalt lymphoma-associated translocation
Target TypeClinical trial target
Gene Age950 ( ENSG00000172175 )
Evolutionary StageEumetazoa
AlphaFoldDBQ9UDY8
Gene CardMALT1
Uniprot IDQ9UDY8
PfamPF13895; PF18703
In ASDyes
Allosteric Predictionyes (0.961374567)
Ortholog in AnimalsAlpaca_ MALT1 ( ortholog_one2one )
Dog_ MALT1 ( ortholog_one2one )
GuineaPig_ MALT1 ( ortholog_one2one )
Macaque_ MALT1 ( ortholog_one2one )
Mouse_ Malt1 ( ortholog_one2one )
Pig_ MALT1 ( ortholog_one2one )
Rat_ Malt1 ( ortholog_one2one )
Rabbit_ MALT1 ( ortholog_one2one )
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityHighly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2G7R  (X-ray  2.70A  )  3BFO  (X-ray  1.15A  )  3K0W  (X-ray  2.80A  )  3UO8  (X-ray  1.90A  )  3UOA  (X-ray  1.75A  )  3V4O  (X-ray  2.10A  )  3V55  (X-ray  1.81A  )  4I1P  (X-ray  2.40A  )  4I1R  (X-ray  2.70A  )  6F7I  (X-ray  2.43A  )  6GK2  (EM  4.90A  )  6H4A  (X-ray  2.65A  )  6YN8  (X-ray  3.05A  )  6YN9  (X-ray  2.56A  )  7A41  (X-ray  2.13A  )  7AK0  (X-ray  2.32A  )  7AK1  (X-ray  2.51A  )  7PAV  (X-ray  2.20A  )  7PAW  (X-ray  2.19A  )  8CZO  (EM  4.30A  ) 
DBSNP rs398123058  rs35533328 
Subcellular location [CC]Cytoplasm, perinuclear region {ECO:0000269|PubMed:16123224}. Nucleus {ECO:0000269|PubMed:16123224}. Note=Shuttles between the nucleus and cytoplasm. Found in perinuclear structures together with BCL10. {ECO:0000269|PubMed:16123224}.
Mouse PG classificationNA
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