| Gene Information | |
|---|---|
| Gene Name | TUBB6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 446 |
| Protein Names | Tubulin beta-6 chain (Tubulin beta class V) |
| Target Name | tubulin beta-6 chain |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000176014 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9BUF5 |
| Gene Card | TUBB6 |
| Uniprot ID | Q9BUF5 |
| Pfam | PF00091; PF03953 |
| In ASD | no |
| Allosteric Prediction | yes (0.152968122) |
| Ortholog in Animals | Alpaca_ TUBB6 ( ortholog_one2one ) Dog_ TUBB6 ( ortholog_one2one ) GuineaPig_ TUBB6 ( ortholog_one2one ) Macaque_ TUBB6 ( ortholog_one2one ) Mouse_ Tubb6 ( ortholog_one2one ) Pig_ TUBB6 ( ortholog_one2one ) Rat_ Tubb6 ( ortholog_one2one ) Rabbit_ TUBB6 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TUBB, TUBA4B, TUBA8, TUBA4A, TUBB3, TUBAL3, TUBG2, TUBB8, TUBB8B, TUBE1, TUBB1, TUBB4B, TUBB4A, TUBA1B, TUBA1A, TUBA1C, TUBA3E, TUBA3C, TUBA3D, TUBD1, TUBG1, TUBB2A, TUBB2B |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. Maximal expression in breast and lung, where it represents around 10% of all beta-tubulins. Largely decreased expression in most cancerous tissues. {ECO:0000269|PubMed:20191564}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1555669248 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton {ECO:0000250}. |
| Mouse PG classification | NA |
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